Publications

Berthoux. 2020. The restrictome of flaviviruses. Virol Sin. Published online 2020-03-20.

Merindol, M. El-Far, M. Sylla, N. Masroori, C. Dufour, J-x Li, P. Cherry, M.B. Plourde, C. Tremblay, L. Berthoux. 2018. HIV-1 capsids from B27/B57+ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state. PLOS Path. 14(11):e1007398.

Dufour, A. Claudel, N. Joubarne, N. Merindol, T. Maisonnet, N. Masroori, M.B. Plourde, L. Berthoux. 2018. Editing of the Human TRIM5 Gene to Introduce Mutations with the Potential to Inhibit HIV-1. PLOSone 13(1): e0191709.

Masroori, P. Cherry, N. Merindol, J.-x. Li, C. Dufour, L. Poulain, M.B. Plourde, L. Berthoux. 2017. Gene Knockout Shows That PML (TRIM19) Does Not Restrict the Early Stages of HIV-1 Infection in Human Cell Lines. mSphere e00233-17.

É. Nepveu-Traversy, A. Demogines, T. Fricke, M.B. Plourde, K. Riopel, M. Veillette, F. Diaz-Griffero, S.L. Sawyer, L. Berthoux. 2016. A putative SUMO interacting motif in the B30.2/SPRY domain of rhesus macaque TRIM5α important for NF-κB/AP-1 signaling and HIV-1 restriction. Heliyon e00056.

Masroori, N. Mérindol, L. Berthoux. 2016. The interferon-induced antiviral protein PML (TRIM19) promotes the restriction and transcriptional silencing of lentiviruses in a context-specific,isoform-specific fashion. Retrovirology 13:19.

Mérindol, L. Berthoux. 2015. Restriction factors in HIV-1 disease progression. Curr. HIV Res. 13:448-61.

Pizzato, M. Neagu, T. Pertel, C. Firrito, S. Ziglio, M. Zufferey, L. Berthoux, J. Luban. 2015. Lv4 is a capsid-specific antiviral activity in human blood cells that restricts viruses of the SIVmac/SIVsm/HIV-2 lineage prior to integration. P.L.O.S. Path. 16(11).

Jung, K. Urak, M. Veillette, M.E. Nepveu-Traversy Q.T. Pham, S. Hamel, J.J. Rossi, L. Berthoux. 2015. Preclinical assessment of mutant human TRIM5α as an anti-HIV-1 transgene. Hum. Gene Ther. 26:664-71.

P. Pawlica, C. Dufour, L. Berthoux. 2015. Inhibition of microtubules and dynein rescues HIV-1 from owl monkey TRIMCyp-mediated restriction in a cellular context-specific fashion. J. Gen. Virol. 96:874-86.

Paquin, A., Oufqir. Y., Sevrioukova, I.F., Reyes-Moreno, C. and Bérubé, G. Innovative C2-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding to recombinant CYP3A4. European Journal of Medicinal Chemistry, 220, 1134965, https://doi.org/10.1016/j.ejmech.2021.113496(nouvelle fenêtre), (*F.I. 5.572).

Paquin, A., Reyes-Moreno, C. and Bérubé, G. Recent advances in the use of the dimerization strategy as a mean to increase the biological potential of natural or synthetic molecules. Molecules, 26(8) :2340, 1-21, https://doi.org/10.3390/molecules26082340(nouvelle fenêtre), (*F.I. 3.589)

Chanphai, P., Cloutier, F., Reyes-Moreno, C., Bérubé, G. and Tajmir-Riahi, H.A.* Binding efficacy of aminobenzoic acid derivatives with DNA duplex: Drug binding sites and DNA structure and dynamics. Journal of Biomolecular Structure & Dynamics, 39(6) :2278-2283, https://doi.org/10.1080/07391102.2020.1740792(nouvelle fenêtre).

Chanphai, P., Cloutier, F., Reyes-Moreno, C., Bérubé, G. and Tajmir-Riahi, H.A. Locating the binding sites of two aminobenzoic acid derivatives on tRNA: Drug binding efficacy and RNA structure. Journal of Biomolecular Structure & Dynamics, Online, https://doi.org/10.1080/07391102.2020.1808076(nouvelle fenêtre), (*F.I.3.549).

Girouard, J., Belgorosky, D., Hamelin-Morrissette, J., Boulanger, V., D'orio, E., Ramla, D., Perron, R., Charpentier, L., Eiján, A.-M., Bérubé, G. and Reyes-Moreno, C. (2020, June). Molecular therapy with derivatives of amino benzoic acid inhibits tumor growth and metastasis in murine models of bladder cancer through inhibition of TNFa/NFkB and iNOS/NO pathways. ScienceDirect, 176,113778,1-15. https://doi.org/10.1016/j.bcp.2019.113778(nouvelle fenêtre). (*F.I.4.980).

Ouellette, V., Côté, M.-F., C.-Gaudreault, R., Tajmir-Riahi, H.-A. and Bérubé, G. Second-generation testosterone-platinum(II) hybrid molecules for site-specific treatment of androgen receptor positive prostate cancer: Design, synthesis and antiproliferative activity. European Journal of Medicinal Chemistry*, 179, 660-666,https://doi.org/10.1016/j.ejmech.2019.06.090(nouvelle fenêtre).

Bérubé, G.* How to utilize academic research efforts in cancer drug discover. Invited Editorial Article, Invited manuscript. Expert Opinion On Drug Discovery, 14 (4),331-334, https://doi.org/10.1080/17460441.2019.1582637(nouvelle fenêtre).

Chanphai, P., Ouellette, V., Mandal, S. K., Bérubé, G. and Tajmir-Riahi, H.A., Testo and testo-Pt(II) bind DNA at different locations, Chemico-Biological Interactions. 296, 179-184, https://doi.org/10.1016/j.cbi.2018.09.008(nouvelle fenêtre).

Singh, A., Massicotte, M.-A., Garand, A., Tousignant, L., Ouellette, V., Bérubé, G., and Desgagné-Penix, I., Cloning and characterization of norbelladine synthase catalyzing the first committed reaction in Amaryllidaceae alkaloid biosynthesis, BMC Plant Biology*, 18:338, pages 1-12, https://doi.org/10.1186/s12870-018-1570-4(nouvelle fenêtre).

Chanphai, P., Ouellette, V., Bérubé, G. and Tajmir-Riahi, H.A., Conjugation of testo and testo-Pt(II) with serum proteins: Loading efficacy and protein conformation, International Journal of Biological Macromolecules*, 118, 1112-1119, https://doi.org/10.1016/j.ijbiomac.2018.06.186(nouvelle fenêtre).

Pepin E, Jalinier T, Lemieux GL</u, Massicotte G and Cyr M (2020) Sphingosine 1-phosphate receptors modulators decrease neuroinflammation and prevent Parkinson’s disease symptoms in the MPTP mouse model. Frontiers in Pharmacology; fphar.2020.00077

Ouimet B, Pépin É, Bergeron Y, Chagniel L, Beaulieu JM, Massicotte G, Cyr M (2019). Motor learning deficits and striatal GSK-3 hyperactivity in Akt3 knockout mice. Behav Neurosci.;133(1):135-143

Hernandez G, Mahmoudi S, Cyr M, Diaz J, Blanchet PJ, Lévesque D (2019). Tardive dyskinesia is associated with altered putamen Akt/GSK-3β signaling in nonhuman primates. Movement Disorders; 34(5):717-726

Bergeron Y, Bureau G, Laurier-Laurin ME, Asselin E, Massicotte G, Cyr M. (2017). Genetic Deletion of Akt3 Induces an Endophenotype Reminiscent of Psychiatric Manifestations in Mice. Frontier in molecular neuroscience. fnmol.2017.00102

St-Cyr Giguère F, Attiori Essis S, Chagniel L, Germain M, Cyr M, Massicotte G. (2017) The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices. Brain Res. 1658:51-59

Masoud ST, Vecchio LM, Bergeron Y, Hossain MM, Nguyen LT, Bermejo MK, Kile B, Sotnikova TD, Siesser WB, Gainetdinov RR, Wightman RM, Caron MG, Richardson JR, Miller GW, Ramsey AJ, Cyr M, and Salahpour A, (2015) Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits. Neurobiol Dis. 74:66-75

Essis SA, Laurier-Laurin ME, Pépin É, Cyr M, Massicotte G. (2015) GluN2B-containing NMDA receptors are upregulated in plasma membranes by the sphingosine-1-phosphate analog FTY720P. Brain Res. doi: 10.1016/j.brainres.2015.07.055.

A Fisette, D Sergi, A Breton-Morin, S Descôteaux, MG Martinoli. « New Insights on the Role of Bioactive Food Derivatives in Neurodegeneration and Neuroprotection.” 2022. Current Pharmaceutical Design. 28(37)

L Décarie*, A Fisette*, Z Zhu, B Yang, RD DiMarchi, MH. Tschöp, B Finan, S Fulton, C Clemmensen. *Co-first author. “GLP-1/Dexamethasone inhibits food reward without inducing mood and memory deficits in mice.” 2019. Neuropharmacology. 19(30).

C Quarta*, A Fisette*, Y Xu, G Colldén, B Legutko, YT Tseng, A Reim, M Wierer, MC De Rosa, V Klaus, R Rausch, VV Thaker, E Graf, TM Strom, AL Poher, T Gruber, O Le Thuc, A Cebrian-Serrano, D Kabra, L Bellocchio, SC Woods, GO Pflugfelder, R Nogueiras, L Zeltser, IC Grunwald Kadow, A Moon, C García-Cáceres, M Mann, M Treier, CA Doege, MH Tschöp. *Co-first author. “Functional identity of hypothalamic melanocortin neurons depends on Tbx3.” 2019. Nature Metabolism. (1). Cover page article, Feb 2019.

S Auguste, S Sharma, A Fisette, C Daneault, C Des Rosiers, S Fulton. “Perinatal deficiency in dietary omega-3 fatty acids potentiates sucrose reward and diet-induced obesity in mice.” 2018. International Journal of Developmental Neuroscience. 64(8).

A Fisette, S Tobin, L Décarie-Spain, K Bouyakdan, ML Peyot, SRM Madiraju, M Prentki, S Fulton, T Alquier. “α/β-hydrolase domain 6 in the ventromedial hypothalamus controls energy metabolism flexibility.” Cell Reports. 17(5).

S Auguste*, A Fisette*, MF Fernandes, C Hryhorczuk, V Poitout, T Alquier, S Fulton. *Co-first author. “Central Agonism of GPR120 Acutely Inhibits Food Intake and Food Reward and Chronically Suppresses Anxiety-Like Behavior in Mice.” 2016. International Journal of Neuropsychopharmacology. 19(7).

A Fisette, T Alquier. “AstroGenesis: And there was leptin on the sixth day.” 2015. Molecular Metabolism. 4(11):755-57

Lounas A, Lebrun A, Laflamme I, Vernoux N, Savage J, Tremblay, M-E, Germain M, Richard F. (2022). Mitochondrial morphology in porcine cumulus cells: a 3D perspective. Scientific Reports. 12:15403: 1-10.

Bilen M, Benhammouda S, Slack RS, Germain M. (2022). The integrated stress response as a key pathway downstream of mitochondrial dysfunction. Current Opinion in Physiology. 28:100555: 1-12.

Tlili M, Acevedo H, Descoteaux A, Germain M, Heinonen KM. (2022). Cell- intrinsic Wnt4 ligand regulates mitochondrial oxidative phosphorylation in macrophages. Biol. Chem.298:102193: 1-15.

Ilamathi HS, Benhammouda S, Desrochers-Goyette J, Lines MA, Germain M. (2022). DRP1 regulates endoplasmic reticulum sheets to control mitochondrial DNA replication and segregation. BioRxiv. 10

Ilamathi HS, Ouellet M, Sabouny R, Desrochers- Goyette J, Lines MA, Pfeffer G, Shutt TE, Germain M. (2021). Mitomate Tracker: an automated tool to quantify nucleoid distribution. Scientific Reports. 11:22755: 1-14.

Klionski D et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (Fourth Edition). Autophagy. 17: 1-382.

Amari L, Germain M. (2021). Mitochondrial Extracellular Vesicles – Origins and Roles. Front. Mol. Neurosci.14:767219: 1-7.

Todkar K, Chikhi L, Desjardins V, El-Mortada F, Pépin G, Germain M. (2021). Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs. Nature Communications. 12:1971: 1-12.

Benhammouda S, Vishwakarma A, Gatti P, Germain M. (2021). Mitochondria Endoplasmic Reticulum Contact Sites (ERMCS): Tools to study organelle interaction. Cell. Dev. Biol.9:789959: 1-6.

Costa G, Caputi FF, Serra M, Simola N, Rullo L, Stamatakos S, Sanna F, Germain M, Martinoli MG, Candeletti S, Morelli M, Romualdi P. (2021). Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related Differences. Pharmacol.12:713486: 1-16.

Gatti P, Ilamathi HS, Todkar K, Germain M. (2020). Mitochondria Targeted Viral Replication and Survival Strategies—Prospective on SARS-CoV-2. Front. Pharmacol.11:578599: 1-9.

Todkar K, Chikhi L, Germain M. (2019). Mitochondrial interaction with the endosomal compartment in endocytosis and mitochondrial transfer. Mitochondrion. 49: 284-288.

Almutawa W, Smith C, Sabouny R, Smit RB, Zhao T, Wong R, Lee-Glover L, Desrochers-Goyette J, Ilamathi HS, Care4Rare Canada Consortium, Suchowersky O, Germain M, Mains PE, Parboosingh JS, Pfeffer G, Innes AM, Shutt TE. (2019). The R941L mutation in MYH14 disrupts mitochondrial fission and causes peripheral neuropathy. EBioMedicine. 45: 379-392.

Lounas A, Vernoux N, Germain M, Tremblay ME, Richard FJ. (2019). Mitochondrial sub-cellular localization of cAMP-specific phosphodiesterase 8A in ovarian follicular cells. Sci. 9:12493: 1-10.

Patten DA, Ouellet M, Allan DS, Baird S, Germain M, Harper ME, Richardson, R. (2018). Mitochondrial adaptation following ionizing radiation in human mesenchymal stem cells. FASEB J. May 21:fj201801483RR: 9263-9278.

Ouellet M, Guillebaud G, Gervais V Lupien St-Pierre D, Germain M. (2017). A novel algorithm identifies stress-induced alterations in mitochondrial connectivity and innermembrane structure from confocal images. PLoS Computational Biology. 13(6): e1005612.

St-Cyr Giguère F, Attiori Essis S, Chagniel L, Germain M, Cyr M, Massicotte G. (2017). The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices. Brain Research. 1658: 51-59.

Todkar K, Ilamathi HS, Germain M. (2017). Mitochondria and Lysosomes: Discovering Bonds. Frontiers in Cell and Developmental Biology. 5(Art. 106): 1-7.

Valet M, Narbonne, P.* (2022) Formation de tumeurs bénignes par dérégulation des cellules souches. PLoS Genet 18(10): e1010434. https://doi.org/10.1371/journal.pgen.1010434

Robinson-Thiewes, S.^w, Dufour, B.^w, Martel, P-O.^w, Lechasseur, X., Danielle Brou, A.A., Roy, V., Chen, Y., Kimble, J. & Narbonne, P.* (2021) Non-autonomous regulation of germline stem cell proliferation by somatic MPK-1/MAPK activity in C. elegans, Cell Reports 35, 109162.

Roy, V., Gagné, O., Hamiche, K., Labbé, J-C., Narbonne, P. (2018) Expression of endogenous PAR-4A & C after CRISPR/Cas9 -mediated genome editing, microPublication Biology* 000075.

Narbonne, P.* (2018) The effect of age on stem cell function and utility for therapy, Cell Medicine 10: 1-9.

Narbonne, P., Maddox, P.S., Labbé, J-C. (2017) DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation, PLoS Genetics* 13(4) : e1006738.

Narbonne, P.^w, Gerhold, A.R.^w, Maddox, P.S., Labbé, J-C. (2016) The C. elegans GSCs: A powerful model for in vivo study of adult stem cell regulation, Int J Stem Cell Res Ther 3: 044.

Narbonne, P., Maddox, P.S., Labbé, J-C. (2015) DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans, Development* 142, 4230-41.

Narbonne, P., Gurdon, J.B. (2012) Amphibian interorder nuclear transfer embryos reveal conserved embryonic gene transcription, but deficient DNA replication or chromosome segregation, The International Journal of Developmental Biology 56: 975-986.

Narbonne, P., Miyamoto, K., Gurdon, J.B. (2012) Reprogramming and development in nuclear transfer embryos and in interspecific systems, Current Opinion in Genetics and Development 22, 450-458.

Narbonne, P., Simpson, D.E., Gurdon, J.B. (2011) Deficient induction response in a Xenopus nucleocytoplasmic hybrid, PLoS Biology 9 (11): e1001197.

Kim, J., Hung, W., Narbonne, P., Roy, R., Zhen, M. (2010) C. elegans STRADa and SAD cooperatively regulate neuronal polarity and synaptic organization, Development 137, 93-102.

Narbonne, P., Roy, R. (2009) Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival, Nature 457, 210-214_._

Narbonne, P., Roy, R. (2008) Genes that affect both cell growth and polarity mediate stem cell quiescence, Frontiers in Bioscience 13, 995-1002.

Narbonne, P., Roy, R. (2006) Regulation of germline stem cell proliferation downstream of nutrient sensing, Cell Division 1:29.

Narbonne, P., Roy, R. (2006) Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling, Development 133, 611-619.

Pepin G, De Nardo D, Rootes CL, Ullah TR, Al-Asmari SS, Balka KR, et al. Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses. mBio. 2020;11(1).

Pepin G, Ferrand J, Honing K, Jayasekara WS, Cain JE, Behlke MA, et al. Cre-dependent DNA recombination activates a STING-dependent innate immune response. Nucleic acids research. 2016;44(11):5356-64.

Pepin G, Gantier MP. cGAS-STING Activation in the Tumor Microenvironment and Its Role in Cancer Immunity. Advances in experimental medicine and biology. 2017;1024:175-94.

Pepin G, Gantier MP. Assessing the cGAS-cGAMP-STING Activity of Cancer Cells. Methods in molecular biology (Clifton, NJ). 2018;1725:257-66.

Pepin G, Nejad C, Ferrand J, Thomas BJ, Stunden HJ, Sanij E, et al. Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses. mBio. 2017;8(5).

Pepin G, Nejad C, Thomas BJ, Ferrand J, McArthur K, Bardin PG, et al. Activation of cGAS-dependent antiviral responses by DNA intercalating agents. Nucleic acids research. 2017;45(1):198-205.

Lien des publications : National Library of Medecine, Erwan Pernet

Khan N, Downey J, Sanz J, Kaufmann E, Blankenhaus B, Pacis A, Pernet E, Ahmed E, Cardoso S, Nijnik A, Mazer B, Sassetti C, Behr MA, Soares MP, Barreiro LB, Divangahi M. M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity. Cell. 2020 Oct 29;183(3):752-770.e22. doi: 10.1016/j.cell.2020.09.062. PMID: 33125891; PMCID: PMC7599081.

 Pernet E, Downey J, Vinh DC, Powell WS, Divangahi M. Leukotriene B4-type I interferon axis regulates macrophage-mediated disease tolerance to influenza infection. Nat Microbiol. 2019 Aug;4(8):1389-1400. doi: 10.1038/s41564-019-0444-3. Epub 2019 May 20. PMID: 31110361.

 Downey J*, Pernet E*, Coulombe F, Allard B, Meunier I, Jaworska J, Qureshi S, Vinh DC, Martin JG, Joubert P, Divangahi M. RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection. PLoS Pathog. 2017 Apr 14;13(4):e1006326. doi: 10.1371/journal.ppat.1006326. PMID: 28410401; PMCID: PMC5406035. *equal contributions

 Divangahi M, King IL, Pernet E. Alveolar macrophages and type I IFN in airway homeostasis and immunity. Trends Immunol. 2015 May;36(5):307-14. doi:10.1016/j.it.2015.03.005. Epub 2015 Apr 3. PMID: 25843635.

 Pernet E, Guillemot L, Burgel PR, Martin C, Lambeau G, Sermet-Gaudelus I, Sands D, Leduc D, Morand PC, Jeammet L, Chignard M, Wu Y, Touqui L. Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity. Nat Commun. 2014 Oct 7;5:5105. doi: 10.1038/ncomms6105. PMID: 25290234.

Denise Belgorosky, Julie Girouard, Yanina Langle, Jovane Hamelin-Morrissette, Lina Marino, Imanol Aguero, Héctor Malagrino, Carlos Reyes-Moreno, Ana María Eiján. Relevance of iNOS expression in tumor growth and maintenance of cancer stem cells in a murine bladder cancer model. Journal of Cellular Physiology, 26 March 2020 (submitted; I. 4.522).

Chanphai, F. Cloutier, C. Reyes-Moreno, G. Bérubé ^^ and H.A. Tajmir-Riahi. Conjugation of aminobenzoic acid derivatives with DNA duplex: Drug binding sites and DNA structure and dynamics. Journal of Molecular Liquids, 3 February 2020 (submitted; F.I. 4.561).

Jovane Hamelin Morrissette, Angham Dallagi, Julie Girouard, Cathy Vaillancourt, Céline Van Themsche, Christian Carrier, Carlos Reyes-Moreno. 2020. Leukemia inhibitory factor regulates the activation of inflammatory signals in macrophages and trophoblast cells. Molecular Immunology, 120: 32-42. https://doi.org/10.1016/j.molimm.2020.01.021(nouvelle fenêtre). (F.I. 3.286).

Chanphai, F. Cloutier, Y. Oufqir, M.-F. Leclerc, A.M. Eiján, C. Reyes-Moreno, G. Bérubé and H.A. Tajmir-Riahi. 2020. Biomolecular study and conjugation of two para-aminobenzoic acid derivatives with serum proteins: drug binding efficacy and protein structural analysis. Journal of Biomolecular Structure & Dynamics, 3:1-12. https://doi.org/10.1080/07391102.2020.1719889(nouvelle fenêtre). (F.I. 3.31).

Girouard, D. Belgorosky, J. Hamelin-Morrissette, V. Boulanger, E. D'orio, D. Ramla, R. Perron, L. Charpentier, A.-M. Eiján, G. Bérubé and C. Reyes-Moreno. 2019. Molecular therapy with derivatives of amino benzoic acid inhibits tumor growth and metastasis in murine models of bladder cancer through inhibition of TNFa/NFkB and iNOS/NO pathways. Biochemical Pharmacology, 113778. https://doi.org/10.1016/j.bcp.2019.113778(nouvelle fenêtre). (F.I. 4.826).

Gervais Bérubé and Carlos Reyes-Moreno. Aminobenzoic acid derivatives for use as anti-inflammatory agents, anti-metastatic agents and/or anticancer agents. World Intellectual Property Organization, WO2017/177316 A1, October 19th, 2017.

Jovane Hamelin Morrissette, Suzie Cloutier, Julie Girouard, Denise Belgorosky, Ana María Eiján, Carlos Reyes-Moreno, and Gervais Bérubé. 2015. Identification of an anti-inflammatory derivative with anti-cancer potential: The impact of each of its structural components on inflammatory responses in macrophages and bladder cancer cells. European Journal of Medicinal Chemistry. 96: 259-268. doi: 10.1016/j.ejmech.2015.04.02 (I. 4.833).

Angham Dallagi, Julie Girouard, Jovane Hamelin-Morrissette, Rachel Dadzie, Laetitia Laurent, Cathy Vaillancourt, Julie Lafond, Christian Carrier, and Carlos Reyes-Moreno. 2014. The activating effect of IFNγ on monocytes/macrophages is regulated by the LIF-trophoblast-IL10 axis through Stat1 inhibition and Stat3 activation. doi: 10.1038/cmi.2014.50. Cellular & Molecular Immunology 2014, 1-16 (I. 7.551).

Leukemia inhibitory factor regulates the activation of inflammatory signals in macrophages and trophoblast cells. Hamelin-Morrissette J, Dallagi A, Girouard J, Ravelojaona M, Oufqir Y, Vaillancourt C, Van Themsche C, Carrier C, Reyes-Moreno C. Mol Immunol. 2020 Feb 8;120:32-42. doi: 10.1016/j.molimm.2020.01.021. [Epub ahead of print]

Molecular therapy with derivatives of amino benzoic acid inhibits tumor growth and metastasis in murine models of bladder cancer through inhibition of TNFα/NFΚB and iNOS/NO pathways. Girouard J, Belgorosky D, Hamelin-Morrissette J, Boulanger V, D'Orio E, Ramla D, Perron R, Charpentier L, Van Themsche C, Eiján AM, Bérubé G, Reyes-Moreno C. Biochem Pharmacol. 2019 Dec 24:113778. doi: 10.1016/j.bcp.2019.113778. [Epub ahead of print]

PAX2 is activated by estradiol in breast cancer cells of the luminal subgroup selectively, to confer a low invasive phenotype. Beauchemin D, Lacombe C, Van Themsche C. Mol Cancer. 2011 Dec 14;10:148. doi: 10.1186/1476-4598-10-148.