Publications

Biondini M., Lehuédé C., Tabariès S., Annis M.G., Pacis A., Ma E.H., Tam C., Hsu B.E., Audet-Delage Y., Abu-Thuraia A., Girondel C., Sabourin V., Totten S.P., De Sa Tavares Russo M., Bridon G., Avizonis D., Guiot M.-C., St-Pierre J., Ursini-Siegel J., Jones R., and Siegel P.M. Metastatic Breast Cancer Cells are Metabolically Reprogrammed to Maintain Redox

Homeostasis during Metastasis. Redox Biology. 75, 103276

Audet-Delage Y., St-Louis C., Minarrieta L., McGuirk S., Kurreal I., Annis M.G., Mer A.S., Siegel P.M., and St-Pierre J. (2023). Spatiotemporal modeling of chemoresistance evolution in breast tumors uncovers dependencies on SLC38A7 and SLC46A1. Cell Reports. 42 (10).

Audet-Delage Y., Rouleau M., Villeneuve L., and Guillemette C. (2022). The Glycosyltransferase Pathway: An Integrated Analysis of the Cell Metabolome. Metabolites. 12 (10), 1006.

McGuirk S., Audet-Delage Y., Annis M.G., Xue Y., Vernier M., Zhao K., St-Louis C., Minarrieta L., Patten D.A., Morin G., Greenwood C.M.T., Giguère V., Huang S., Siegel P.M., and St-Pierre J. (2021). Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer. eLife. 10, e65150.

McGuirk S., Audet-Delage Y., and St-Pierre J. (2020) Metabolic Fitness and Plasticity in Cancer Progression. Trends in Cancer 6, 49-61. Co-premier auteur. 

Berthoux. 2020. The restrictome of flaviviruses. Virol Sin. Published online 2020-03-20.

Merindol, M. El-Far, M. Sylla, N. Masroori, C. Dufour, J-x Li, P. Cherry, M.B. Plourde, C. Tremblay, L. Berthoux. 2018. HIV-1 capsids from B27/B57+ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state. PLOS Path. 14(11):e1007398.

Dufour, A. Claudel, N. Joubarne, N. Merindol, T. Maisonnet, N. Masroori, M.B. Plourde, L. Berthoux. 2018. Editing of the Human TRIM5 Gene to Introduce Mutations with the Potential to Inhibit HIV-1. PLOSone 13(1): e0191709.

Masroori, P. Cherry, N. Merindol, J.-x. Li, C. Dufour, L. Poulain, M.B. Plourde, L. Berthoux. 2017. Gene Knockout Shows That PML (TRIM19) Does Not Restrict the Early Stages of HIV-1 Infection in Human Cell Lines. mSphere e00233-17.

É. Nepveu-Traversy, A. Demogines, T. Fricke, M.B. Plourde, K. Riopel, M. Veillette, F. Diaz-Griffero, S.L. Sawyer, L. Berthoux. 2016. A putative SUMO interacting motif in the B30.2/SPRY domain of rhesus macaque TRIM5α important for NF-κB/AP-1 signaling and HIV-1 restriction. Heliyon e00056.

Masroori, N. Mérindol, L. Berthoux. 2016. The interferon-induced antiviral protein PML (TRIM19) promotes the restriction and transcriptional silencing of lentiviruses in a context-specific,isoform-specific fashion. Retrovirology 13:19.

Mérindol, L. Berthoux. 2015. Restriction factors in HIV-1 disease progression. Curr. HIV Res. 13:448-61.

Pizzato, M. Neagu, T. Pertel, C. Firrito, S. Ziglio, M. Zufferey, L. Berthoux, J. Luban. 2015. Lv4 is a capsid-specific antiviral activity in human blood cells that restricts viruses of the SIVmac/SIVsm/HIV-2 lineage prior to integration. P.L.O.S. Path. 16(11).

Jung, K. Urak, M. Veillette, M.E. Nepveu-Traversy Q.T. Pham, S. Hamel, J.J. Rossi, L. Berthoux. 2015. Preclinical assessment of mutant human TRIM5α as an anti-HIV-1 transgene. Hum. Gene Ther. 26:664-71.

P. Pawlica, C. Dufour, L. Berthoux. 2015. Inhibition of microtubules and dynein rescues HIV-1 from owl monkey TRIMCyp-mediated restriction in a cellular context-specific fashion. J. Gen. Virol. 96:874-86.

Pepin E, Jalinier T, Lemieux GL</u, Massicotte G and Cyr M (2020) Sphingosine 1-phosphate receptors modulators decrease neuroinflammation and prevent Parkinson’s disease symptoms in the MPTP mouse model. Frontiers in Pharmacology; fphar.2020.00077

Ouimet B, Pépin É, Bergeron Y, Chagniel L, Beaulieu JM, Massicotte G, Cyr M (2019). Motor learning deficits and striatal GSK-3 hyperactivity in Akt3 knockout mice. Behav Neurosci.;133(1):135-143

Hernandez G, Mahmoudi S, Cyr M, Diaz J, Blanchet PJ, Lévesque D (2019). Tardive dyskinesia is associated with altered putamen Akt/GSK-3β signaling in nonhuman primates. Movement Disorders; 34(5):717-726

Bergeron Y, Bureau G, Laurier-Laurin ME, Asselin E, Massicotte G, Cyr M. (2017). Genetic Deletion of Akt3 Induces an Endophenotype Reminiscent of Psychiatric Manifestations in Mice. Frontier in molecular neuroscience. fnmol.2017.00102

St-Cyr Giguère F, Attiori Essis S, Chagniel L, Germain M, Cyr M, Massicotte G. (2017) The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices. Brain Res. 1658:51-59

Masoud ST, Vecchio LM, Bergeron Y, Hossain MM, Nguyen LT, Bermejo MK, Kile B, Sotnikova TD, Siesser WB, Gainetdinov RR, Wightman RM, Caron MG, Richardson JR, Miller GW, Ramsey AJ, Cyr M, and Salahpour A, (2015) Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits. Neurobiol Dis. 74:66-75

Essis SA, Laurier-Laurin ME, Pépin É, Cyr M, Massicotte G. (2015) GluN2B-containing NMDA receptors are upregulated in plasma membranes by the sphingosine-1-phosphate analog FTY720P. Brain Res. doi: 10.1016/j.brainres.2015.07.055.

A Fisette, D Sergi, A Breton-Morin, S Descôteaux, MG Martinoli. « New Insights on the Role of Bioactive Food Derivatives in Neurodegeneration and Neuroprotection.” 2022. Current Pharmaceutical Design. 28(37)

L Décarie*, A Fisette*, Z Zhu, B Yang, RD DiMarchi, MH. Tschöp, B Finan, S Fulton, C Clemmensen. *Co-first author. “GLP-1/Dexamethasone inhibits food reward without inducing mood and memory deficits in mice.” 2019. Neuropharmacology. 19(30).

C Quarta*, A Fisette*, Y Xu, G Colldén, B Legutko, YT Tseng, A Reim, M Wierer, MC De Rosa, V Klaus, R Rausch, VV Thaker, E Graf, TM Strom, AL Poher, T Gruber, O Le Thuc, A Cebrian-Serrano, D Kabra, L Bellocchio, SC Woods, GO Pflugfelder, R Nogueiras, L Zeltser, IC Grunwald Kadow, A Moon, C García-Cáceres, M Mann, M Treier, CA Doege, MH Tschöp. *Co-first author. “Functional identity of hypothalamic melanocortin neurons depends on Tbx3.” 2019. Nature Metabolism. (1). Cover page article, Feb 2019.

S Auguste, S Sharma, A Fisette, C Daneault, C Des Rosiers, S Fulton. “Perinatal deficiency in dietary omega-3 fatty acids potentiates sucrose reward and diet-induced obesity in mice.” 2018. International Journal of Developmental Neuroscience. 64(8).

A Fisette, S Tobin, L Décarie-Spain, K Bouyakdan, ML Peyot, SRM Madiraju, M Prentki, S Fulton, T Alquier. “α/β-hydrolase domain 6 in the ventromedial hypothalamus controls energy metabolism flexibility.” Cell Reports. 17(5).

S Auguste*, A Fisette*, MF Fernandes, C Hryhorczuk, V Poitout, T Alquier, S Fulton. *Co-first author. “Central Agonism of GPR120 Acutely Inhibits Food Intake and Food Reward and Chronically Suppresses Anxiety-Like Behavior in Mice.” 2016. International Journal of Neuropsychopharmacology. 19(7).

A Fisette, T Alquier. “AstroGenesis: And there was leptin on the sixth day.” 2015. Molecular Metabolism. 4(11):755-57

Gatti P*, Schiavon C, Manor U, Germain M. (2025). Mitochondria- and ER-associated actin are required for mitochondrial fusion. Nature Communications. 16:451

Talukdar PD, Pramanik K, Gatti P*, Mukherjee P, Ghosh D, Roy H, Germain M, Chatterji U. (2025). Precise targeting of transcriptional co-activators YAP/TAZ annihilates chemoresistant breast cancer stem cells by alteration of their mitochondrial homeostasis. Signal Transduction and Targeted Therapy. In press

Lounas A*, Breton Y, Lebrun A, Laflamme I, Vernoux N, Savage J, Tremblay ME, Pelletier M, Germain M, Richard FJ. (2024). The follicle-stimulating hormone triggers rapid changes in mitochondrial structure and function in porcine cumulus cells. Scientific Reports. 14:436

Ilamathi HS*, Benhammouda S*, Chatel-Chaix L, Germain M. (2024). Measuring interorganelle contact sites in primary cells using a modified proximity ligation assay. STAR Protocols. 5: 102915

Ilamathi HS*, Germain M. (2023). ER-mitochondria contact sites in nucleoid dynamics, maintenance, and distribution. International Journal of Biochemistry and Cell Biology. 166(166:106492): 1-4.

Ilamathi HS*, Benhammouda S*, Desrochers-Goyette J*, Lines MA, Germain M. (2023). DRP1 regulates endoplasmic reticulum sheets to control mitochondrial DNA replication and segregation. iScience. 26: 1-24.

Lounas A, Lebrun A, Laflamme I, Vernoux N, Savage J, Tremblay, M-E, Germain M, Richard F. (2022). Mitochondrial morphology in porcine cumulus cells: a 3D perspective. Scientific Reports. 12:15403: 1-10.

Bilen M, Benhammouda S, Slack RS, Germain M. (2022). The integrated stress response as a key pathway downstream of mitochondrial dysfunction. Current Opinion in Physiology. 28:100555: 1-12.

Tlili M, Acevedo H, Descoteaux A, Germain M, Heinonen KM. (2022). Cell- intrinsic Wnt4 ligand regulates mitochondrial oxidative phosphorylation in macrophages. Biol. Chem.298:102193: 1-15.

Ilamathi HS*, Ouellet M*, Sabouny R, Desrochers- Goyette J*, Lines MA, Pfeffer G, Shutt TE, Germain (2021). Mitomate Tracker: an automated tool to quantify nucleoid distribution. Sci. Rep. 11:22755: 1-14.

Benhammouda S*, Vishwakarma A*, Gatti P*, Germain M*. (2021). Mitochondria Endoplasmic Reticulum Contact Sites (ERMCS): Tools to study organelle interaction. Frontiers in Cell Dev. Biol. 9:789959

Klionski D et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (Fourth Edition) [The authors include a large number of labs working on autophagy (including my lab) by alphabetical order]. Autophagy. 17: 1-382.

Amari L*, Germain M. (2021). Mitochondrial Extracellular Vesicles – Origins and Roles. Front. Mol. Neurosci. 14:767219.

Todkar K*, Chikhi L*, Desjardins V*, El-Mortada F*, Pépin G, Germain M. (2021). Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs. Nature Communications. 12:1971: 1-12.

Costa G, Caputi FF, Serra M, Simola N, Rullo L, Stamatakos S, Sanna F, Germain M, Martinoli MG, Candeletti S, Morelli M, Romualdi P. (2021). Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related Differences. Front. Pharmacol.12:713486: 1-16.

Gatti P*, Ilamathi HS*, Todkar K*, Germain M. (2020). Mitochondria Targeted Viral Replication and Survival Strategies—Prospective on SARS-CoV-2. Front. Pharmacol.11:578599: 1-9.

Todkar K*, Chikhi L*, Germain M. (2019). Mitochondrial interaction with the endosomal compartment in endocytosis and mitochondrial transfer. Mitochondrion. 49: 284-288.

Almutawa W, Smith C, Sabouny R, Smit RB, Zhao T, Wong R, Lee-Glover L, Desrochers-Goyette J*, Ilamathi HS*, Care4Rare Canada Consortium, Suchowersky O, Germain M, Mains PE, Parboosingh JS, Pfeffer G, Innes AM, Shutt TE. (2019). The R941L mutation in MYH14 disrupts mitochondrial fission and causes peripheral neuropathy. EBioMedicine. 45: 379-392.

Lounas A*, Vernoux N, Germain M, Tremblay ME, Richard FJ. (2019). Mitochondrial sub-cellular localization of cAMP-specific phosphodiesterase 8A in ovarian follicular cells. Sci. 9:12493: 1-10.

Patten DA, Ouellet M*, Allan DS, Baird S, Germain M, Harper ME, Richardson, R. (2018). Mitochondrial adaptation following ionizing radiation in human mesenchymal stem cells. FASEB J. May 21:fj201801483RR: 9263-9278.

Ouellet M*, Guillebaud G*, Gervais V* Lupien St-Pierre D, Germain M. (2017). A novel algorithm identifies stress-induced alterations in mitochondrial connectivity and innermembrane structure from confocal images. PLoS Computational Biology. 13(6): e1005612.

St-Cyr Giguère F, Attiori Essis S, Chagniel L, Germain M, Cyr M, Massicotte G. (2017). The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices. Brain Research. 1658: 51-59.

Todkar K*, Ilamathi HS*, Germain M. (2017). Mitochondria and Lysosomes: Discovering Bonds. Frontiers in Cell and Developmental Biology. 5(Art. 106): 1-7.

Achour I, Arel-Dubeau AM, Renaud J, Legrand M, Attard E, Germain M, Martinoli MG. (2016). Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model. International Journal of Molecular Sciences. 17: pii: E1293.

Khacho M, Clark A, Svoboda DS, Azzi J, MacLaurin J, Meghaizel C, Sesaski H, Lagace DC, Germain M, Harper ME, Park DS, Slack RS. (2016). Mitochondrial dynamics directs the identity and self-renewal capacity of stem cells by regulating a nuclear transcriptional program. Cell Stem Cell. 19(2): 232-247.

Demers-Lamarche J*, Guillebaud G*, Todkar K*, Tlili M*, Bélanger N*, Nguyen AP, Grondin M*, Michel J, Germain M. (2016). Loss of mitochondrial function impairs lysosomes. J. Biol. Chem. 291(19): 10263-10276.

Desjardins K, Taherkhani S, Méthot L, Castonguay V, Leduc-Gaudet JP. (2024) Insights into the influence of high-intensity interval training on skeletal muscle clock gene expression in insulin-resistant individuals. Journal of physiologyhttps://doi.org/10.1113/JP286939 

Roussel MP, Ravel-Chapuis A, Gobin J, Jasmin BJ, Leduc-Gaudet JP, Gagnon C, Duchesne E. (2024) Changes in Physiopathological Markers in Myotonic Dystrophy Type 1 Skeletal Muscle: A 3-Year Follow-up Study. Journal of Neuromuscular Diseases

Sedraoui S, Leduc-Gaudet JP, Mayaki D, Moamer A, Huck L, Gouspillou G, Petrof B, Hussain SNA. (2024) Lack of compensatory mitophagy in skeletal muscles during sepsis. Journal of physiologyhttps://doi.org/10.1113/JP286216

Girard-Côté L, Gallais B, Gagnon Cynthia, Roussel MP, Morin M, Hébert LJ, Monckton D, Leduc-Gaudet JP, Gouspillou G, Macangelli V, Duchesne E. (2024) Resistance training in women with DM1: a multisystemic therapeutic avenue. Neuromuscular Disordershttps://doi.org/10.1016/j.nmd.2024.05.009

Cefis M, Dargegen M, Marcangeli V, Taherkhani S, Dulac M, Leduc-Gaudet JP, Mayaki D, Hussain SNA, (2024) Gouspillou G. MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission.  Acta Physiologicahttps://doi.org/10.1111/apha.14119

Leduc-Gaudet JP#, Miguez K, Cefis M, Faitg J, Moamer A, Chaffer TJ, Reynaud O, Broering FE, Shams A, Mayaki D, Huck L, Sandri M, Gouspillou G#, Hussain SNA#. Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival. #Auteur correspondant. (2023) ISciencehttps://www.sciencedirect.com/science/article/pii/S2589004223015523 

Leduc-Gaudet JP, Guirguis C, Sincennes MC. Emerging links between metabolism and epigenetic regulation of muscle stem cells. (2023) Med Sci (Paris)PMID: 37387661

Franco-Romero A*,Leduc-Gaudet JP*, Hussain SNA, Gouspillou G, Sandri S. PHAF1/MYTHO is a novel autophagy regulator that controls muscle integrity. *Co-premier auteur. (2023) AutophagyPMID: 37309183

Leduc-Gaudet JP*, Franco-Romero A*, Broering F, Cefis M, Moamer A, et al. MYTHO: a novel regulator of skeletal muscle autophagy and integrity.*Co-premier auteur. (2023) Nature Communications PMID:36864049

Reynaud O, Wang J, Ayoub MB, Leduc-Gaudet JP, Mayaki D, Dulac M, Hussain S, Bergeron R, and Gouspillou G. The impact of high fat feeding and Parkin overexpression on skeletal muscle mass, mitochondrial respiration and H2O2 (2022) American Journal of Physiology-Cell PhysiologyPMID:36571445

Leduc-Gaudet JP, Hussain SNA, Gouspillou G, (2022) Parkin: A potential target to promote healthy aging.The Journal of physiology PMID:36571445

Gusev E, Liang F, Bhattarai S, Broering F, Leduc-Gaudet JP, Hussain SNA, Radzioch D, and Petrof B. (2022) Characterization of skeletal muscle wasting pathways in diaphragm and limb muscles of cystic fibrosis mice.American Journal of Physiology-Regulatory, Integrative and Comparative Physiology PMID:35411814

Leduc-Gaudet JPand Hussain SNA, (2022) Muscle wasting in COPD: Not enough autophagy? American Journal of Respiratory Cell and Molecular Biology PMID:35294850

Chaffer T, Cefis M, Leduc-Gaudet JP, Circadian control of skeletal muscle adaptations to exercise.The Journal of physiology PMID:34339519

Leduc-Gaudet JP#, Hussain SNA, Barreiro E, and Gouspillou G. (2021) Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging. #Auteur correspondant. International Journal of Molecular SciencesPMID:34360946

Dulac M, Leduc-Gaudet JP, Cefis M, Ayoub MB, Reynaud O, Shams A, et al. (2021) Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice.The Journal of physiology PMID:34269418 

Leduc-Gaudet JP, Miguez K, Cefis M, Moamer A, Chaffer TJ, Faitg J, et al. Role of autophagy in sepsis-induced skeletal muscle dysfunction, whole-body metabolism, and survival.(2021) bioRxiv

Klionsky, D. J., (...) Leduc-Gaudet JP, (...) et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy(4th edition). Autophagy PMID:33634751 

Leduc-Gaudet JP, Mayaki D, Reynaud O, Broering F, Chaffer T, Hussain SNA and Gouspillou G.(2020) Parkin Overexpression Attenuates Sepsis-Induced Muscle Wasting. CellsPMID: 32545383

Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub M.B, Guérin A, Finkelchtein M, et al. (2020). Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation.The Journal of physiology PMID: 32539155

Janice Sanchez B, Tremblay, AK, Leduc-Gaudet JP, Hall DT, Kovacs E, Ma JF, Mubaid S, Hallauer, et al. (2019). Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy.Nature Communication PMID: 31519904

Leduc-Gaudet JP*, Reynaud O*, Hussain SNA, Gouspillou G. (2019) Parkin overexpression protects from aging-related loss of muscle mass and strength. *Co-premier auteur. The Journal of PhysiologyPMID:30614532

Faitg J, Leduc-Gaudet JP, Reynaud O, Ferland G, Gaudreau P, Gouspillou G. (2019) Effects of aging and caloric restriction on mitochondrial morphology and dynamics in rat oxidative and glycolytic muscles.Frontiers in Physiology PMID: 31114501

Moroz N, Maes K, Leduc-Gaudet JP, Goldberg P, Petrof BJ, Mayaki D. et al. (2019) Oxidant regulation of muscle proteolytic pathways in the diaphragm during prolonged mechanical ventilation. AnesthesiologyPMID: 31408447

Leduc-Gaudet JP, Reynaud O, Chabot F, Mercier J, Andrich DE, St-Pierre DH, Gouspillou G. (2018) The impact of a short-term high-fat diet on mitochondrial respiration, reactive oxygen species production, and dynamics in oxidative and glycolytic skeletal muscles of young rats. Physiological ReportsPMID: 29479852

St-Jean-Pelletier F, Pion CH, Leduc-Gaudet JP, Sgarioto N, Zovile I, Barbat-Artigas S, Reynaud O, Alkaterji F, Lemieux FC, Grenon A, Gaudreau P, Hepple RT, Chevalier S, Belanger M, Morais JA, Aubertin-Leheudre M, Gouspillou G. (2017) The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men.The Journal of Cachexia, Sarcopenia and Muscle PMID: 27897402

Stana F, Vujovic M, Mayaki D, Leduc-Gaudet JP, Leblanc P, Huck L, Hussain SNA. (2017) Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis.Critical Care Medicine PMID: 28538438   

Leduc-Gaudet JP, Picard M, St-Jean Pelletier F, Sgarioto N, Auger MJ, Vallée J, Robitaille R, St-Pierre DH, Gouspillou G. (2015) Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice. Oncotarget PMID: 26053100

Complete list: https://pubmed.ncbi.nlm.nih.gov/?term=Leduc-Gaudet+JP&cauthor_id=28538438&size=50  

Turmel-Couture, S., Martel, P-O., Beaulieu, L., Lechasseur, X., Fotso, L.& Narbonne, P.* (2024) Bidirectional transfer of a small membrane-impermeable molecule between the Caenorhabditis elegans intestine and germline, J Biol Chem 300(12): 107963.

McGuirk S., Audet-Delage Y., and St-Pierre J. (2020) Metabolic Fitness and Plasticity in Cancer Progression. Trends in Cancer 6, 49-61. Co-premier auteur. 

Valet M, Narbonne, P.* (2022) Formation de tumeurs bénignes par dérégulation des cellules souches. PLoS Genet 18(10): e1010434. https://doi.org/10.1371/journal.pgen.1010434

Robinson-Thiewes, S.^w, Dufour, B.^w, Martel, P-O.^w, Lechasseur, X., Danielle Brou, A.A., Roy, V., Chen, Y., Kimble, J. & Narbonne, P.* (2021) Non-autonomous regulation of germline stem cell proliferation by somatic MPK-1/MAPK activity in C. elegans, Cell Reports 35, 109162.

Roy, V., Gagné, O., Hamiche, K., Labbé, J-C., Narbonne, P. (2018) Expression of endogenous PAR-4A & C after CRISPR/Cas9 -mediated genome editing, microPublication Biology* 000075.

Narbonne, P.* (2018) The effect of age on stem cell function and utility for therapy, Cell Medicine 10: 1-9.

Narbonne, P., Maddox, P.S., Labbé, J-C. (2017) DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation, PLoS Genetics* 13(4) : e1006738.

Narbonne, P.^w, Gerhold, A.R.^w, Maddox, P.S., Labbé, J-C. (2016) The C. elegans GSCs: A powerful model for in vivo study of adult stem cell regulation, Int J Stem Cell Res Ther 3: 044.

Narbonne, P., Maddox, P.S., Labbé, J-C. (2015) DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans, Development* 142, 4230-41.

Narbonne, P., Gurdon, J.B. (2012) Amphibian interorder nuclear transfer embryos reveal conserved embryonic gene transcription, but deficient DNA replication or chromosome segregation, The International Journal of Developmental Biology 56: 975-986.

Narbonne, P., Miyamoto, K., Gurdon, J.B. (2012) Reprogramming and development in nuclear transfer embryos and in interspecific systems, Current Opinion in Genetics and Development 22, 450-458.

Narbonne, P., Simpson, D.E., Gurdon, J.B. (2011) Deficient induction response in a Xenopus nucleocytoplasmic hybrid, PLoS Biology 9 (11): e1001197.

Kim, J., Hung, W., Narbonne, P., Roy, R., Zhen, M. (2010) C. elegans STRADa and SAD cooperatively regulate neuronal polarity and synaptic organization, Development 137, 93-102.

Narbonne, P., Roy, R. (2009) Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival, Nature 457, 210-214_._

Narbonne, P., Roy, R. (2008) Genes that affect both cell growth and polarity mediate stem cell quiescence, Frontiers in Bioscience 13, 995-1002.

Narbonne, P., Roy, R. (2006) Regulation of germline stem cell proliferation downstream of nutrient sensing, Cell Division 1:29.

Narbonne, P., Roy, R. (2006) Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling, Development 133, 611-619.

Pepin G, De Nardo D, Rootes CL, Ullah TR, Al-Asmari SS, Balka KR, et al. Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses. mBio. 2020;11(1).

Pepin G, Ferrand J, Honing K, Jayasekara WS, Cain JE, Behlke MA, et al. Cre-dependent DNA recombination activates a STING-dependent innate immune response. Nucleic acids research. 2016;44(11):5356-64.

Pepin G, Gantier MP. cGAS-STING Activation in the Tumor Microenvironment and Its Role in Cancer Immunity. Advances in experimental medicine and biology. 2017;1024:175-94.

Pepin G, Gantier MP. Assessing the cGAS-cGAMP-STING Activity of Cancer Cells. Methods in molecular biology (Clifton, NJ). 2018;1725:257-66.

Pepin G, Nejad C, Ferrand J, Thomas BJ, Stunden HJ, Sanij E, et al. Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses. mBio. 2017;8(5).

Pepin G, Nejad C, Thomas BJ, Ferrand J, McArthur K, Bardin PG, et al. Activation of cGAS-dependent antiviral responses by DNA intercalating agents. Nucleic acids research. 2017;45(1):198-205.

Lien des publications : National Library of Medecine, Erwan Pernet

Khan N, Downey J, Sanz J, Kaufmann E, Blankenhaus B, Pacis A, Pernet E, Ahmed E, Cardoso S, Nijnik A, Mazer B, Sassetti C, Behr MA, Soares MP, Barreiro LB, Divangahi M. M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity. Cell. 2020 Oct 29;183(3):752-770.e22. doi: 10.1016/j.cell.2020.09.062. PMID: 33125891; PMCID: PMC7599081.

 Pernet E, Downey J, Vinh DC, Powell WS, Divangahi M. Leukotriene B4-type I interferon axis regulates macrophage-mediated disease tolerance to influenza infection. Nat Microbiol. 2019 Aug;4(8):1389-1400. doi: 10.1038/s41564-019-0444-3. Epub 2019 May 20. PMID: 31110361.

 Downey J*, Pernet E*, Coulombe F, Allard B, Meunier I, Jaworska J, Qureshi S, Vinh DC, Martin JG, Joubert P, Divangahi M. RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection. PLoS Pathog. 2017 Apr 14;13(4):e1006326. doi: 10.1371/journal.ppat.1006326. PMID: 28410401; PMCID: PMC5406035. *equal contributions

 Divangahi M, King IL, Pernet E. Alveolar macrophages and type I IFN in airway homeostasis and immunity. Trends Immunol. 2015 May;36(5):307-14. doi:10.1016/j.it.2015.03.005. Epub 2015 Apr 3. PMID: 25843635.

 Pernet E, Guillemot L, Burgel PR, Martin C, Lambeau G, Sermet-Gaudelus I, Sands D, Leduc D, Morand PC, Jeammet L, Chignard M, Wu Y, Touqui L. Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity. Nat Commun. 2014 Oct 7;5:5105. doi: 10.1038/ncomms6105. PMID: 25290234.

Khiat, N., Girouard, J., Kana Tsapi, E. S., Vaillancourt, C., Van Themsche, C., & Reyes-Moreno, C. (2025). TGFβ1 Restores Energy Homeostasis of Human Trophoblast Cells Under Hyperglycemia In Vitro by Inducing PPARγ Expression, AMPK Activation, and HIF1α Degradation. Cells, 14 :45. https://doi.org/10.3390/cells14010045 (F.I. : 5.1).

Marion Ravelojaona, Julie Girouard, Megan Chambers, Tyler Joseph, Cathy Thornton, Carlos Reyes-Moreno. (2024). Regulatory role of Leukemia Inhibitory Factor (LIF) and Oncostatin M (OSM) in the maintenance of cell populations involved in intrauterine inflammation at the fetal-maternal interface. Placenta, 154: e41. https://doi.org/10.1016/j.placenta.2024.07.172 (I : 3)

Marion Ravelojaona, Julie Girouard, Emmanuelle Stella Kana Tsapi, Megan Chambers, Cathy Vaillancourt, Céline Van Themsche, Catherine A Thornton, and Carlos Reyes-Moreno. (2024). Oncostatin M and STAT3 Signaling Pathways Support Human Trophoblast Differentiation by Inhibiting Inflammatory Stress in Response to IFNg and GM-CSF. Cells, 13:229. https://doi.org/10.3390/cells13030229 (F.I.: 5.1).

Paquin A, Fortin L, Girouard J, Reyes-Moreno C, Sevrioukova IF, Bérubé G. (2023). Investigating a new C2-symmetric testosterone dimer and its dihydrotestosterone analog: Synthesis, antiproliferative activity on prostate cancer cell lines and interaction with CYP3A4. European Journal of Medicinal Chemistry, 250:115222. doi: 10.1016/j.ejmech.2023.115222 (F.I.: 7.088).

Yassine Oufqir, Laurie Fortin, Julie Girouard, Francis Cloutier, Maude Cloutier, Marie-France Leclerc, Denise Belgorosky, Ana María Eiján, Gervais Bérubé and Carlos Reyes-Moreno. (2022). Synthesis of new para-aminobenzoic acid derivatives, in vitro biological evaluation and preclinical validation of DAB-2-28 as a therapeutic option for the treatment of bladder cancer. European Journal of Medicinal Chemistry Report, 6, 100069. https://doi.org/10.1016/j.ejmcr.2022.100069. (I.: 4).

Francis Cloutier, Yassine Oufqir, Laurie Fortin, Marie-France Leclerc, Julie Girouard, Heidar-Ali Tajmir-Riahi, Carlos Reyes-Moreno and Gervais Bérubé. (2022). Design of novel 4-maleimidylphenyl-hydrazides molecules displaying anti-inflammatory properties: refining the chemical structure. European Journal of Medicinal Chemistry Report, 5: https://doi.org/10.1016/j.ejmcr.2022.100064 (F.I.: 4).

Denise Belgorosky, Julie Girouard, Yanina Langle, Jovane Hamelin-Morrissette, Lina Marino, Imanol Aguero, Héctor Malagrino, Carlos Reyes-Moreno, Ana María Eiján. Relevance of iNOS expression in tumor growth and maintenance of cancer stem cells in a murine bladder cancer model. Journal of Cellular Physiology, 26 March 2020 (submitted; I. 4.522).

Chanphai, F. Cloutier, C. Reyes-Moreno, G. Bérubé ^^ and H.A. Tajmir-Riahi. Conjugation of aminobenzoic acid derivatives with DNA duplex: Drug binding sites and DNA structure and dynamics. Journal of Molecular Liquids, 3 February 2020 (submitted; F.I. 4.561).

Jovane Hamelin Morrissette, Angham Dallagi, Julie Girouard, Cathy Vaillancourt, Céline Van Themsche, Christian Carrier, Carlos Reyes-Moreno. 2020. Leukemia inhibitory factor regulates the activation of inflammatory signals in macrophages and trophoblast cells. Molecular Immunology, 120: 32-42. https://doi.org/10.1016/j.molimm.2020.01.021(nouvelle fenêtre). (F.I. 3.286).

Chanphai, F. Cloutier, Y. Oufqir, M.-F. Leclerc, A.M. Eiján, C. Reyes-Moreno, G. Bérubé and H.A. Tajmir-Riahi. 2020. Biomolecular study and conjugation of two para-aminobenzoic acid derivatives with serum proteins: drug binding efficacy and protein structural analysis. Journal of Biomolecular Structure & Dynamics, 3:1-12. https://doi.org/10.1080/07391102.2020.1719889(nouvelle fenêtre). (F.I. 3.31).

Girouard, D. Belgorosky, J. Hamelin-Morrissette, V. Boulanger, E. D'orio, D. Ramla, R. Perron, L. Charpentier, A.-M. Eiján, G. Bérubé and C. Reyes-Moreno. 2019. Molecular therapy with derivatives of amino benzoic acid inhibits tumor growth and metastasis in murine models of bladder cancer through inhibition of TNFa/NFkB and iNOS/NO pathways. Biochemical Pharmacology, 113778. https://doi.org/10.1016/j.bcp.2019.113778(nouvelle fenêtre). (F.I. 4.826).

Gervais Bérubé and Carlos Reyes-Moreno. Aminobenzoic acid derivatives for use as anti-inflammatory agents, anti-metastatic agents and/or anticancer agents. World Intellectual Property Organization, WO2017/177316 A1, October 19th, 2017.

Jovane Hamelin Morrissette, Suzie Cloutier, Julie Girouard, Denise Belgorosky, Ana María Eiján, Carlos Reyes-Moreno, and Gervais Bérubé. 2015. Identification of an anti-inflammatory derivative with anti-cancer potential: The impact of each of its structural components on inflammatory responses in macrophages and bladder cancer cells. European Journal of Medicinal Chemistry. 96: 259-268. doi: 10.1016/j.ejmech.2015.04.02 (I. 4.833).

Angham Dallagi, Julie Girouard, Jovane Hamelin-Morrissette, Rachel Dadzie, Laetitia Laurent, Cathy Vaillancourt, Julie Lafond, Christian Carrier, and Carlos Reyes-Moreno. 2014. The activating effect of IFNγ on monocytes/macrophages is regulated by the LIF-trophoblast-IL10 axis through Stat1 inhibition and Stat3 activation. doi: 10.1038/cmi.2014.50. Cellular & Molecular Immunology 2014, 1-16 (I. 7.551).