Desgagné-Penix, Isabel (co-directrice)

BIOCHIMISTE INTÉRESSÉ PAR LE MÉTABOLISME SECONDAIRE DES ALCALOÏDES DES AMARYLLIDACEAE

Curriculum Court  

Stage Post-Doctoral en biochimie / génomique appliquée, Université de Calgary
Doctorat en biologie moléculaire et cellulaire, University of Texas à San Antonio
Maîtrise en immunologie / biologie cellulaire, Université de Sherbrooke

Intérêts de recherche 

Métabolisme secondaire, alcaloïdes, biologie des systèmes, biologie synthétique, ingénierie métabolique, Amaryllidaceae.  

Coordonnées

Courriel : Isabel.Desgagne-Penix@uqtr.ca
Téléphone : (819) 376-5011, poste 3316 

Affiliations 

SEVE: Centre de recherche interinstitutionnel en sciences du végétal / Université de Sherbrooke  

Autres sites 

Site web personnel 
Page du département de chimie, biochimie et physique de l'UQTR

Publications

Desgagné-Penix, I. 2015. Early biosynthetic steps of Amaryllidaceae alkaloid metabolism. Planta, submitted.

Hotchandani, T. and Desgagné-Penix, I. 2015. Heterocyclic Amaryllidaceae alkaloids: Biosynthesis and pharmacological applications. Curr. Top. Med. Chem., submitted.

Diamond, A. and Desgagné-Penix, I. 2015. Metabolic engineering and synthetic biology for the production of plant isoquinoline alkaloids. Plant Biotech. J., submitted.

Hagel, JM., Lee, E-J., Desgagné-Penix, I., Bross, CD., Chang, L., Chen, X., Farrow, SC., Zhang,Y., Soh, J., Sensen, CW., Facchini, PJ. 2015. Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants. BMC Plant Biol, accepted.

Singh, A. and Desgagné-Penix, I. 2014. Biosynthesis of Amaryllidaceae alkaloids. Plant Science Today 1(3): 114-120.

Xiao, M., Zhang, Y., Lee, E.-J., Chen, X., Barber, C.J.S., Chakrabarty^, R., Desgagné-Penix, I., Haslam, T.M., Kim, Y.-B., Liu, E., Masada-Atsumi, S., MacNevin, G., Reed, D.W., Stout, J.M., Zerbe, P., Zhang, Y., Bohlmann, J., Covello, P.S., De Luca, V., Page, J.E., Ro, D.-K., Martin, V.J.J., Facchini, P.F., and Sensen, C.W. 2013. Transcriptome analysis based on next-generation sequencing of non-model plants producing specialized metabolites of biotechnological interest. J. of Biotechnol. 166: 122-134.

Desgagné-Penix, I. and Facchini, P.J. 2012. Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major route to papaverine in opium poppy. Plant J. 72: 331-344.

Desgagné-Penix, I., Farrow, S.C., Cram, D., Nowak, J. and Facchini, P.J. 2012. Integration of deep transcript and targeted metabolite profiling of eight cultivars of opium poppy. Plant Mol Biology 79: 295-313.

Desgagné-Penix, I., Khan, M.F., Schriemer, D.C., Cram, D., Nowak, J. and Facchini, P.J. 2010. Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures. BMC Plant Biology 10: 252-268.

Desgagné-Penix, I., Hagel, J.M. and Facchini, P.J. (2009) Mutagenesis as a functional genomics platform for pharmaceutical alkaloid biosynthetic gene discovery in opium poppy. Proc. FAO/IAEA International Symposium on Induced Mutations in Plants. pp 411-418.

Desgagné-Penix, I. and Sponsel, V.M. 2008. Expression of gibberellin 20-oxidase1 (AtGA20ox1) in Arabidopsis seedlings with altered auxin status is regulated at multiple levels. J. Exp. Bot. 59: 2057-2070.

Desgagné-Penix, I., Eakanunkul, S., Coles, J.P., Phillips, A.L., Hedden, P. and Sponsel, V.M. 2005. The auxin transport inhibitor response 3 (tir3) allele of BIG and auxin transport inhibitors affect the gibberellin status of Arabidopsis. The Plant J. 41: 231-242.

Chapître de livre:

Singh, A.and Desgagné-Penix, I. 2015. Chapter 3 : Biosynthesis of Amaryllidaceae alkaloids: A biochemical outlook. In: Alkaloids: Biosynthesis, Biological Roles and Health benefits, pp. 53-76. Nova Science Publishers, Eduardo Sobarzo-Sanchez editor. February 2015

Desgagné-Penix, I. and Facchini, P.J. 2011. Chap. 9 Biosynthesis of benzylisoquinoline alkaloids. In: Plant Metabolism and Biotechnology. John Wiley & Son Publishing, Hiroshi Ashihara editor. ISBN: 978-0-470-74703-2, April 2011

Profil Research Gate 

Étudiant(e)s

Ph.D. : Aparna Singh

M.Sc. : Tarun Hotchandani, Andrew Diamond