Jean-Philippe Leduc Gaudet

Page personnelle

• 2020-2023 : Post-doctorat en physiologie musculaire (Université de Padoue / IR-CUSM et Institut Vénitien de Médecine Moléculaire)
• 2016-2020 : Ph.D. en Physiologie et physiopathologie musculaire (Université McGill)
• 2014-2016 : M. Sc. en Physiologie mitochondriale (Université du Québec à Montréal)
• 2011-2014 : B. Sc. en Kinésiolgie/physiologie de l'exercice (Université du Québec à Montréal)

- Mécanismes de l'atrophie musculaire

- Maladies métaboliques

- Biologie mitochondriale

- Vieillissement musculaire (sarcopénie) 

- Maladies neuromusculaires

- Physiologie de l'exercice

- Physiologie et physiopathologie musculaire

- Membre du comité de révision des demandes de bourses doctorales du FRQS - 2024-2025

- Membre du comité de révision des demandes de bourses d'inititiation à la recherche au 1er cycle du FRQS - 2023-2024

QUELQUES PUBLICATIONS

Sélection:

1. Reynaud, O, Ayoub, MB, Leduc-Gaudet, JP, Cefis, M, Lussier, MP, Hussain, SN et al.. Parkin overexpression attenuates muscle atrophy and improves mitochondrial bioenergetics but not histological features of Duchenne muscular dystrophy in mice. Sci Rep. 2026.16 (1)4139 https://pubmed.ncbi.nlm.nih.gov/41547930/
2. Rihoux, A, Sutton, E, Lee, J, Flewwelling, L, Garibotti, M, Osman, H et al.. 2nd NMD4C basic research summer school on promoting standardized protocols to advance translational research in neuromuscular disorders. J Neuromuscul Dis. 2025. 22143602251408154 https://pubmed.ncbi.nlm.nih.gov/41417778/ #Auteur correspondant.
3. Marcangeli, V, Girard-Côté, L, Di Leo, V, Roussel, MP, Lawless, C, Charest, O et al.. A 12-Week Strength Training Improves Mitochondrial Respiration, H₂O₂ Emission and Skeletal Muscle Integrity in Women With Myotonic Dystrophy Type 1. Acta Physiol (Oxf). 2025.241 (12)e7013 https://pubmed.ncbi.nlm.nih.gov/41241935/ #Auteur correspondant.
4. Morin, E, Doumard, E, Hartnell, LM, Salegi Ansa, B, Leduc-Gaudet, JP, Quillien, Aet al.. EMito-Metrix enables automated evaluation of mitochondrial morphology across species. Nat Metab. 2025.7 (11)2179-2182 https://pubmed.ncbi.nlm.nih.gov/41094017/
5. Marcangeli, V, Cefis, M, Hammad, R, Granet, J, Leduc-Gaudet, JP, Gaudreau, Pet al.. Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans. Aging Cell. 2025.24 (10)e70191 https://pubmed.ncbi.nlm.nih.gov/41061678/
6. Cefis, M, Marcangeli, V, Hammad, R, Granet, J, Leduc-Gaudet, JP, Gaudreau, Pet al.. Impact of physical activity on physical function, mitochondrial energetics, ROS production, and Ca²⁺ handling across the adult lifespan in men. Cell Rep Med. 2025.6 (2)101968 https://pubmed.ncbi.nlm.nih.gov/39933528/ 
7. Desjardins K, Taherkhani S, Méthot L, Castonguay V, Leduc-Gaudet JP. (2024) Insights into the influence of high-intensity interval training on skeletal muscle clock gene expression in insulin-resistant individuals. Journal of physiology https://doi.org/10.1113/JP286939 
8. Roussel MP, Ravel-Chapuis A, Gobin J, Jasmin BJ, Leduc-Gaudet JP, Gagnon C, Duchesne E. (2024) Changes in Physiopathological Markers in Myotonic Dystrophy Type 1 Skeletal Muscle: A 3-Year Follow-up Study. Journal of Neuromuscular Diseases
9. Sedraoui S, Leduc-Gaudet JP, Mayaki D, Moamer A, Huck L, Gouspillou G, Petrof B, Hussain SNA. (2024) Lack of compensatory mitophagy in skeletal muscles during sepsis. Journal of physiology https://doi.org/10.1113/JP286216
10. Girard-Côté L, Gallais B, Gagnon Cynthia, Roussel MP, Morin M, Hébert LJ, Monckton D, Leduc-Gaudet JP, Gouspillou G, Macangelli V, Duchesne E. (2024) Resistance training in women with DM1: a multisystemic therapeutic avenue. Neuromuscular Disorders https://doi.org/10.1016/j.nmd.2024.05.009
11. Cefis M, Dargegen M, Marcangeli V, Taherkhani S, Dulac M, Leduc-Gaudet JP, Mayaki D, Hussain SNA, (2024) Gouspillou G. MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H₂O₂ emission.  Acta Physiologica https://doi.org/10.1111/apha.14119
12. Leduc-Gaudet JP#, Miguez K, Cefis M, Faitg J, Moamer A, Chaffer TJ, Reynaud O, Broering FE, Shams A, Mayaki D, Huck L, Sandri M, Gouspillou G#, Hussain SNA#. Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival. #Auteur correspondant. (2023) IScience https://www.sciencedirect.com/science/article/pii/S2589004223015523 
13. Leduc-Gaudet JP, Guirguis C, Sincennes MC. Emerging links between metabolism and epigenetic regulation of muscle stem cells. (2023) Med Sci (Paris) PMID: 37387661
14. Franco-Romero A*,Leduc-Gaudet JP*, Hussain SNA, Gouspillou G, Sandri S. PHAF1/MYTHO is a novel autophagy regulator that controls muscle integrity. *Co-premier auteur. (2023) Autophagy PMID: 37309183
15. Leduc-Gaudet JP*, Franco-Romero A*, Broering F, Cefis M, Moamer A, et al. MYTHO: a novel regulator of skeletal muscle autophagy and integrity. *Co-premier auteur. (2023) Nature Communications PMID:36864049
16. Reynaud O, Wang J, Ayoub MB, Leduc-Gaudet JP, Mayaki D, Dulac M, Hussain S, Bergeron R, and Gouspillou G. The impact of high fat feeding and Parkin overexpression on skeletal muscle mass, mitochondrial respiration and H₂O₂ (2022) American Journal of Physiology-Cell Physiology PMID:36571445
17. Leduc-Gaudet JP, Hussain SNA, Gouspillou G, (2022) Parkin: A potential target to promote healthy aging. The Journal of physiology PMID:36571445
18. Gusev E, Liang F, Bhattarai S, Broering F, Leduc-Gaudet JP, Hussain SNA, Radzioch D, and Petrof B. (2022) Characterization of skeletal muscle wasting pathways in diaphragm and limb muscles of cystic fibrosis mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology PMID:35411814
19. Leduc-Gaudet JP and Hussain SNA, (2022) Muscle wasting in COPD: Not enough autophagy? American Journal of Respiratory Cell and Molecular Biology PMID:35294850
20. Chaffer T, Cefis M, Leduc-Gaudet JP, Circadian control of skeletal muscle adaptations to exercise. The Journal of physiology PMID:34339519
21. Leduc-Gaudet JP#, Hussain SNA, Barreiro E, and Gouspillou G. (2021) Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging. #Auteur correspondant. International Journal of Molecular Sciences PMID:34360946
22. Dulac M, Leduc-Gaudet JP, Cefis M, Ayoub MB, Reynaud O, Shams A, et al. (2021) Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice. The Journal of physiology PMID:34269418 
23. Leduc-Gaudet JP, Miguez K, Cefis M, Moamer A, Chaffer TJ, Faitg J, et al. Role of autophagy in sepsis-induced skeletal muscle dysfunction, whole-body metabolism, and survival. (2021) bioRxiv
24. Klionsky, D. J., (...) Leduc-Gaudet JP, (...) et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy PMID:33634751 
25. Leduc-Gaudet JP, Mayaki D, Reynaud O, Broering F, Chaffer T, Hussain SNA and Gouspillou G.(2020) Parkin Overexpression Attenuates Sepsis-Induced Muscle Wasting. Cells PMID: 32545383
26. Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub M.B, Guérin A, Finkelchtein M, et al. (2020). Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation. The Journal of physiology PMID: 32539155
27. Janice Sanchez B, Tremblay, AK, Leduc-Gaudet JP, Hall DT, Kovacs E, Ma JF, Mubaid S, Hallauer, et al. (2019). Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy. Nature Communication PMID: 31519904
28. Leduc-Gaudet JP*, Reynaud O*, Hussain SNA, Gouspillou G. (2019) Parkin overexpression protects from aging-related loss of muscle mass and strength. *Co-premier auteur. The Journal of Physiology PMID:30614532
29. Faitg J, Leduc-Gaudet JP, Reynaud O, Ferland G, Gaudreau P, Gouspillou G. (2019) Effects of aging and caloric restriction on mitochondrial morphology and dynamics in rat oxidative and glycolytic muscles. Frontiers in Physiology PMID: 31114501
30. Moroz N, Maes K, Leduc-Gaudet JP, Goldberg P, Petrof BJ, Mayaki D. et al. (2019) Oxidant regulation of muscle proteolytic pathways in the diaphragm during prolonged mechanical ventilation. Anesthesiology PMID: 31408447
31. Leduc-Gaudet JP, Reynaud O, Chabot F, Mercier J, Andrich DE, St-Pierre DH, Gouspillou G. (2018) The impact of a short-term high-fat diet on mitochondrial respiration, reactive oxygen species production, and dynamics in oxidative and glycolytic skeletal muscles of young rats. Physiological Reports PMID: 29479852
32. St-Jean-Pelletier F, Pion CH, Leduc-Gaudet JP, Sgarioto N, Zovile I, Barbat-Artigas S, Reynaud O, Alkaterji F, Lemieux FC, Grenon A, Gaudreau P, Hepple RT, Chevalier S, Belanger M, Morais JA, Aubertin-Leheudre M, Gouspillou G. (2017) The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men. The Journal of Cachexia, Sarcopenia and Muscle PMID: 27897402
33. Stana F, Vujovic M, Mayaki D, Leduc-Gaudet JP, Leblanc P, Huck L, Hussain SNA. (2017) Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis. Critical Care Medicine PMID: 28538438   
34. Leduc-Gaudet JP, Picard M, St-Jean Pelletier F, Sgarioto N, Auger MJ, Vallée J, Robitaille R, St-Pierre DH, Gouspillou G. (2015) Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice. Oncotarget PMID: 26053100

Liste complète: https://pubmed.ncbi.nlm.nih.gov/?term=Leduc-Gaudet+JP&cauthor_id=28538438&size=50 

2025: Financement de l’Agence spatiale canadienne 

2024: Récipiendaire d'une subvention à la découverte du CRSNG

2024: Récipiendaire du Discovery Award 2024 de la Banting Research Foundation

2023: NMD4C Biomedical Publication of the Year award

2021: FRQS Postdoctoral Fellowship

2020: Journal of Physiology Early Investigator Prize 2019 - Exercise and Muscle

2016: Vanier Canada Graduate Scholarship (CIHR)

2015: Lieutenant Governor’s Youth Medal (Bronze) 

2015: FRQS Master’s Research Scholarship

2014: Frederick Banting and Charles Best Canada Graduate Scholarship

2014: Strathcona Trust Plaque

Jean-Philippe Leduc-Gaudet veut renverser la perte de masse musculaire

L’importance de l’autophagie musculaire lors du sepsis

Des chercheurs de l’IR-CUSM identifient un nouveau gène, régulateur de l’autophagie