Jean-Philippe Leduc Gaudet
Professeur
Cours enseignés
Automne 2024
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BIP6024
- Séminaire
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BIP6027
- Projet de thèse
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BIP6030
- Biologie cellulaire et moléculaire avancée
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BIP6033
- Sujets spéciaux en biologie médicale
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PSL1004
- Physiologie humaine I
Hiver 2025
Intérêts de recherche
- Mécanismes de l'atrophie musculaire
- Maladies métaboliques
- Biologie mitochondriale
- Vieillissement musculaire (sarcopénie)
- Maladies neuromusculaires
- Physiologie de l'exercice
- Physiologie et physiopathologie musculaire
Quelques communications et publications
QUELQUES PUBLICATIONS
Sélection:
- Desjardins K, Taherkhani S, Méthot L, Castonguay V, Leduc-Gaudet JP. (2024) Insights into the influence of high-intensity interval training on skeletal muscle clock gene expression in insulin-resistant individuals. Journal of physiology https://doi.org/10.1113/JP286939
- Roussel MP, Ravel-Chapuis A, Gobin J, Jasmin BJ, Leduc-Gaudet JP, Gagnon C, Duchesne E. (2024) Changes in Physiopathological Markers in Myotonic Dystrophy Type 1 Skeletal Muscle: A 3-Year Follow-up Study. Journal of Neuromuscular Diseases
- Sedraoui S, Leduc-Gaudet JP, Mayaki D, Moamer A, Huck L, Gouspillou G, Petrof B, Hussain SNA. (2024) Lack of compensatory mitophagy in skeletal muscles during sepsis. Journal of physiology https://doi.org/10.1113/JP286216
- Girard-Côté L, Gallais B, Gagnon Cynthia, Roussel MP, Morin M, Hébert LJ, Monckton D, Leduc-Gaudet JP, Gouspillou G, Macangelli V, Duchesne E. (2024) Resistance training in women with DM1: a multisystemic therapeutic avenue. Neuromuscular Disorders https://doi.org/10.1016/j.nmd.2024.05.009
- Cefis M, Dargegen M, Marcangeli V, Taherkhani S, Dulac M, Leduc-Gaudet JP, Mayaki D, Hussain SNA, (2024) Gouspillou G. MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission. Acta Physiologica https://doi.org/10.1111/apha.14119
- Leduc-Gaudet JP#, Miguez K, Cefis M, Faitg J, Moamer A, Chaffer TJ, Reynaud O, Broering FE, Shams A, Mayaki D, Huck L, Sandri M, Gouspillou G#, Hussain SNA#. Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival. #Auteur correspondant. (2023) IScience https://www.sciencedirect.com/science/article/pii/S2589004223015523
- Leduc-Gaudet JP, Guirguis C, Sincennes MC. Emerging links between metabolism and epigenetic regulation of muscle stem cells. (2023) Med Sci (Paris) PMID: 37387661
- Franco-Romero A*,Leduc-Gaudet JP*, Hussain SNA, Gouspillou G, Sandri S. PHAF1/MYTHO is a novel autophagy regulator that controls muscle integrity. *Co-premier auteur. (2023) Autophagy PMID: 37309183
- Leduc-Gaudet JP*, Franco-Romero A*, Broering F, Cefis M, Moamer A, et al. MYTHO: a novel regulator of skeletal muscle autophagy and integrity. *Co-premier auteur. (2023) Nature Communications PMID:36864049
- Reynaud O, Wang J, Ayoub MB, Leduc-Gaudet JP, Mayaki D, Dulac M, Hussain S, Bergeron R, and Gouspillou G. The impact of high fat feeding and Parkin overexpression on skeletal muscle mass, mitochondrial respiration and H2O2 (2022) American Journal of Physiology-Cell Physiology PMID:36571445
- Leduc-Gaudet JP, Hussain SNA, Gouspillou G, (2022) Parkin: A potential target to promote healthy aging. The Journal of physiology PMID:36571445
- Gusev E, Liang F, Bhattarai S, Broering F, Leduc-Gaudet JP, Hussain SNA, Radzioch D, and Petrof B. (2022) Characterization of skeletal muscle wasting pathways in diaphragm and limb muscles of cystic fibrosis mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology PMID:35411814
- Leduc-Gaudet JP and Hussain SNA, (2022) Muscle wasting in COPD: Not enough autophagy? American Journal of Respiratory Cell and Molecular Biology PMID:35294850
- Chaffer T, Cefis M, Leduc-Gaudet JP, Circadian control of skeletal muscle adaptations to exercise. The Journal of physiology PMID:34339519
- Leduc-Gaudet JP#, Hussain SNA, Barreiro E, and Gouspillou G. (2021) Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging. #Auteur correspondant. International Journal of Molecular Sciences PMID:34360946
- Dulac M, Leduc-Gaudet JP, Cefis M, Ayoub MB, Reynaud O, Shams A, et al. (2021) Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice. The Journal of physiology PMID:34269418
- Leduc-Gaudet JP, Miguez K, Cefis M, Moamer A, Chaffer TJ, Faitg J, et al. Role of autophagy in sepsis-induced skeletal muscle dysfunction, whole-body metabolism, and survival. (2021) bioRxiv
- Klionsky, D. J., (...) Leduc-Gaudet JP, (...) et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy PMID:33634751
- Leduc-Gaudet JP, Mayaki D, Reynaud O, Broering F, Chaffer T, Hussain SNA and Gouspillou G.(2020) Parkin Overexpression Attenuates Sepsis-Induced Muscle Wasting. Cells PMID: 32545383
- Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub M.B, Guérin A, Finkelchtein M, et al. (2020). Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation. The Journal of physiology PMID: 32539155
- Janice Sanchez B, Tremblay, AK, Leduc-Gaudet JP, Hall DT, Kovacs E, Ma JF, Mubaid S, Hallauer, et al. (2019). Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy. Nature Communication PMID: 31519904
- Leduc-Gaudet JP*, Reynaud O*, Hussain SNA, Gouspillou G. (2019) Parkin overexpression protects from aging-related loss of muscle mass and strength. *Co-premier auteur. The Journal of Physiology PMID:30614532
- Faitg J, Leduc-Gaudet JP, Reynaud O, Ferland G, Gaudreau P, Gouspillou G. (2019) Effects of aging and caloric restriction on mitochondrial morphology and dynamics in rat oxidative and glycolytic muscles. Frontiers in Physiology PMID: 31114501
- Moroz N, Maes K, Leduc-Gaudet JP, Goldberg P, Petrof BJ, Mayaki D. et al. (2019) Oxidant regulation of muscle proteolytic pathways in the diaphragm during prolonged mechanical ventilation. Anesthesiology PMID: 31408447
- Leduc-Gaudet JP, Reynaud O, Chabot F, Mercier J, Andrich DE, St-Pierre DH, Gouspillou G. (2018) The impact of a short-term high-fat diet on mitochondrial respiration, reactive oxygen species production, and dynamics in oxidative and glycolytic skeletal muscles of young rats. Physiological Reports PMID: 29479852
- St-Jean-Pelletier F, Pion CH, Leduc-Gaudet JP, Sgarioto N, Zovile I, Barbat-Artigas S, Reynaud O, Alkaterji F, Lemieux FC, Grenon A, Gaudreau P, Hepple RT, Chevalier S, Belanger M, Morais JA, Aubertin-Leheudre M, Gouspillou G. (2017) The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men. The Journal of Cachexia, Sarcopenia and Muscle PMID: 27897402
- Stana F, Vujovic M, Mayaki D, Leduc-Gaudet JP, Leblanc P, Huck L, Hussain SNA. (2017) Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis. Critical Care Medicine PMID: 28538438
- Leduc-Gaudet JP, Picard M, St-Jean Pelletier F, Sgarioto N, Auger MJ, Vallée J, Robitaille R, St-Pierre DH, Gouspillou G. (2015) Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice. Oncotarget PMID: 26053100
Liste complète: https://pubmed.ncbi.nlm.nih.gov/?term=Leduc-Gaudet+JP&cauthor_id=28538438&size=50
Prix et distinctions
2024: Récipiendaire d'une subvention à la découverte du CRSNG
2024: Récipiendaire du Discovery Award 2024 de la Banting Research Foundation
2023: NMD4C Biomedical Publication of the Year award
2021: FRQS Postdoctoral Fellowship
2020: Journal of Physiology Early Investigator Prize 2019 - Exercise and Muscle
2016: Vanier Canada Graduate Scholarship (CIHR)
2015: Lieutenant Governor’s Youth Medal (Bronze)
2015: FRQS Master’s Research Scholarship
2014: Frederick Banting and Charles Best Canada Graduate Scholarship
2014: Strathcona Trust Plaque
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