Éric Asselin,  Ph.D. Directeur du groupe de recherche, Chaire de recherche du Canada en gynéco-oncologie moléculaire

3501c, Léon-Provancher (bientôt : 2006 Pierre-Boucher)
Téléphone : 819 376-5011 poste 3317
Télécopieur : 819 376-5084
 
Équipe de recherche :
Professionnelle : Sophie Parent
Étudiants gradués : Marie-Claude Déry
Véronique Gagnon
Valérie Leblanc
Isabelle Mathieu
Carl Shooner
Marie-Ève St-Germain
 
  Formation académique :
Post-doc: Fonction ovarienne et oncologie, Loeb Health Research Institute, Hôpital Civique d'Ottawa, Université d'Ottawa (1999-2000)
Post-doc: Reproduction animale, Animal science department, Institute of Bioscience & Technology, Université Texas A&M, College Station, USA (1998-1999)
Ph.D: Physiologie et Endocrinologie, Université Laval, Québec (1998)
B.Sc: Biochimie, Université Laval, Québec (1994)
 
  Affiliations :
Society for the Study of Reproduction (SSR)
Société Canadienne de Fertilité et d'Andrologie (SCFA)
American Association for Cancer Research (AACR)
 
  Enseignement :
Physiologie de la Reproduction (PLS-1016)
Étude de cas en Biologie Moléculaire (BLM-1008)
Biologie Moléculaire Médicale (BLM-1007)
 
  Champs d'expertise :
Biologie moléculaire
Biologie cellulaire
Expérimentations animales in vivo et in vitro
 
  Projets de recherche :
Développement de modèles animaux in vitro et in vivo pour l'étude des mécanismes impliqués dans la reconnaissance de la gestation.
Le rôle de l'apoptose dans l'utérus au cours du cycle oestral, de l'implantation embryonnaire et de la régression de la décidue pendant la gestation.
Étude du cancer ovarien et endométrial humain: Apoptose, thérapie génique et chimiothérapie
Projets de recherche financés par le Fond de la Recherche en Santé du Québec (FRSQ), Fond de Recherche sur la Nature et les Technologies du Québec (FRNTQ) et le Conseil de Recherches en Sciences Naturelles et en Génie du Canada (CRSNG).
 
  Publications choisies :
Leblanc V, Dery MC, Shooner C, Asselin E. Opposite regulation of XIAP and Smac/DIABLO in the rat endometrium in response to 17beta-estradiol at estrus.Reprod Biol Endocrinol. 2003 Aug 27; 1(1):59.  www.rbej.com/content/1/1/59
Dery MC, Leblanc V, Shooner C, Asselin E. Regulation of Akt expression and phosphorylation by 17beta-estradiol in the rat uterus during estrous cycle. Reprod Biol Endocrinol. 2003 Jun 12; 1(1):47.  www.rbej.com/content/1/1/47
Gagnon V, St-Germain ME, Parent S, Asselin E. Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1. Int J Oncol. 2003 Sep; 23(3):803-10.
St-Germain ME, Gagnon V, Parent S and Asselin E. Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells. Biology of Reproduction (2003); submitted.
Wang YF, Asselin E, Tsang BK. Involvement of TGFa in the FSH regulation of Rat Ovarian X-linked Inhibitor of Apoptosis Protein Expression and Follicular Growth. Biology of Reproduction (2002); 66: 1672-1680.
Xiao CW, Asselin E, Tsang BK. NFkB-mediated induction of Flice-like Inhibitory Protein (FLIP) prevents tumor necrosis factor-a-induced apoptosis in rat granulosa cells. Biology of Reproduction (2002); 67:436-441.
Asselin E, Mills GB, Tsang BK. Xiap regulates akt activity and its caspase-3-dependent cleavage during cisplatin induced-apoptosis in human epithelial ovarian cancer cells. Cancer Research (2001); 61: 1862-1868.
Asselin E, Wang YF, Tsang BK. X-linked inhibitor of apoptosis protein activates phosphatidylinositol 3-kinase/akt pathway in rat granulosa cells during follicular development. Endocrinology (2001); 142 : 2451-2457.
Asselin E, Johnson GA, Spencer TA and Bazer FW. Expression of monocyte chemotactic protein-1 and -2 in the ovine uterus: regulation by pregnancy, progesterone and interferon-tau. Biology of Reproduction (2001); 64 : 939-941.
Asselin E, Xiao CW, Wang YF and Tsang BK Mammalian follicular development and atresia: the role of apoptosis. Biological Signals and Receptors (2000); 9:87-95.
Emond V, Asselin E, Fortier MA, Murphy BD and Lambert RD. Interferon-tau stimulates granulocyte-macrophage colony-stimulating factor gene expression in bovine lymphocytes and endometrial stromal cells. Biology of Reproduction (2000); 62:1728-1737.
Asselin E and Fortier MA. Detection and regulation of the messenger for a putative bovine endometrial 9-keto-PGE2 reductase: effect of oxytocin and roIFN-t Biology of Reproduciton (2000); 62: 125-131.
Lapointe S, Lemieux D, Asselin E, Fortier MA and Sirard MA. Epithelial and stromal cells cultured in vitro protect bovine sperm from hydrogene peroxide. Theriogenology (2000); 54: 355-369.
Asselin E, Drolet P and Fortier MA. In vitro response to oxytocin and interferon-tau in bovine endometrial cells from caruncular and inter-caruncular areas. Biology of Reproduction, 1998; 59: 241-247.
Asselin E, Drolet P and Fortier MA. Cellular mechanisms involved during oxytocin-induced PGF2a production in endometrial epithelial cells in vitro: role of cyclooxygenase-2. Endocrinology, 1997; 138: 4798-4805.
Asselin E, Lacroix D and Fortier MA. IFN-tau increases PGE2 production and COX-2 gene expression in the bovine endometrium in vitro. Molecular and Cellular Endocrinology, 1997; 132: 117-126.
Fortier MA, Doualla-Bell F, Asselin E and Lambert RD. Prostaglandins are primary regulators of conceptus-maternal interactions underlying successfull pregnancy. Journal of the Society of Obstetricians and Gynaecologists of Canada, 1997; 19:
Asselin E, Bazer FW and Fortier MA. Recombinant ovine and bovine interferons tau regulates prostaglandins production and oxytocin responses in cultured bovine endometrial cells. Biology of Reproduction, 1997; 56: 402-408.
 
  Communications choisies :
Asselin E, St-Germain ME, Gagnon V and Parent S. Regulation of COX-2 and PGE2 production in human endometrial cancer cells through PI 3-K/Akt pathway. Signalling the future: Meeting of the Physiological Society, Society for Endocrinology, and British Society for Developmental Biology. University of Liverpool, UK. 3-7 Septembre 2002.
Parent S, St-Germain ME, Gagnon V and Asselin E. Influence of PTEN mutation on Akt and bcl-2 in human endometrial cancer cells. Signalling the future: Meeting of the Physiological Society, Society for Endocrinology, and British Society for Developmental Biology. University of Liverpool, UK. 3-7 Septembre 2002.
Dery MC, Shooner C, Parent S and Asselin E. Involvement of the PI 3-K/Akt pathway in the regulation of apoptosis in the rat endometrium during estrous cycle. Baltimore, Maryland, USA. July 2002. Biol Reprod. Vol. 66, Suppl. 1, Abstract #549.
Shooner C, Déry MC, Parent S and Asselin E. Regression of the decidua during rat pregnancy is mediated through apoptosis and inhibition af Akt activity. 35th annual meeting of the Society for the Study of Reproduction. Baltimore, Maryland, USA. July 2002. Biol Reprod. Vol. 66, Suppl. 1, Abstract #565.