Jean-Philippe Leduc Gaudet
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Jean-Philippe Leduc Gaudet
Professeur
Langues parlées
  • Français
  • Anglais
Réseaux sociaux
Twitter Research Gate
Mots-clés
Formation
  • 2020-2023 : Post-doctorat en physiologie musculaire (Université de Padoue / IR-CUSM et Institut Vénitien de Médecine Moléculaire)
  • 2016-2020 : Ph.D. en Physiologie et physiopathologie musculaire (Université McGill)
  • 2014-2016 : M. Sc. en Physiologie mitochondriale (Université du Québec à Montréal)
  • 2011-2014 : B. Sc. en Kinésiolgie/physiologie de l'exercice (Université du Québec à Montréal)

Champ d'intérêt / Domaine d'expertise

- Mécanismes de l'atrophie musculaire

- Maladies métaboliques

- Biologie mitochondriale

- Vieillissement musculaire (sarcopénie) 

- Maladies neuromusculaires

- Physiologie de l'exercice

- Physiologie et physiopathologie musculaire

Liste des cours enseignés
Sigle Titre
BIP6024 Séminaire
BIP6027 Projet de thèse
BIP6030 Biologie cellulaire et moléculaire avancée
PSL1004 Physiologie humaine I
PSL1018 Physiologie humaine clinique
Service à la collectivité

- Membre du comité de révision des demandes de bourses doctorales du FRQS - 2024-2025

- Membre du comité de révision des demandes de bourses d'inititiation à la recherche au 1er cycle du FRQS - 2023-2024

Publications

QUELQUES PUBLICATIONS

Sélection:

  1. Leduc-Gaudet JP#, Miguez K, Cefis M, Faitg J, Moamer A, Chaffer TJ, Reynaud O, Broering FE, Shams A, Mayaki D, Huck L, Sandri M, Gouspillou G#, Hussain SNA#. Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival. #Auteur correspondant. (2023) IScience https://www.sciencedirect.com/science/article/pii/S2589004223015523 
  2. Leduc-Gaudet JP, Guirguis C, Sincennes MC. Emerging links between metabolism and epigenetic regulation of muscle stem cells. (2023) Med Sci (Paris) PMID: 37387661
  3. Franco-Romero A*,Leduc-Gaudet JP*, Hussain SNA, Gouspillou G, Sandri S. PHAF1/MYTHO is a novel autophagy regulator that controls muscle integrity. *Co-premier auteur(2023) Autophagy PMID: 37309183
  4. Leduc-Gaudet JP*, Franco-Romero A*, Broering F, Cefis M, Moamer A, et al. MYTHO: a novel regulator of skeletal muscle autophagy and integrity. *Co-premier auteur(2023) Nature Communications PMID:36864049
  5. Reynaud O, Wang J, Ayoub MB, Leduc-Gaudet JP, Mayaki D, Dulac M, Hussain S, Bergeron R, and Gouspillou G. The impact of high fat feeding and Parkin overexpression on skeletal muscle mass, mitochondrial respiration and H2O2 (2022) American Journal of Physiology-Cell Physiology PMID:36571445
  6. Leduc-Gaudet JP, Hussain SNA, Gouspillou G, (2022) Parkin: A potential target to promote healthy aging. The Journal of physiology PMID:36571445
  7. Gusev E, Liang F, Bhattarai S, Broering F, Leduc-Gaudet JP, Hussain SNA, Radzioch D, and Petrof B. (2022) Characterization of skeletal muscle wasting pathways in diaphragm and limb muscles of cystic fibrosis mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology PMID:35411814
  8. Leduc-Gaudet JP and Hussain SNA, (2022) Muscle wasting in COPD: Not enough autophagy? American Journal of Respiratory Cell and Molecular Biology PMID:35294850
  9. Chaffer T, Cefis M, Leduc-Gaudet JP, Circadian control of skeletal muscle adaptations to exercise. The Journal of physiology PMID:34339519
  10. Leduc-Gaudet JP#, Hussain SNA, Barreiro E, and Gouspillou G. (2021) Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging. #Auteur correspondant. International Journal of Molecular Sciences PMID:34360946
  11. Dulac M, Leduc-Gaudet JP, Cefis M, Ayoub MB, Reynaud O, Shams A, et al. (2021) Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice. The Journal of physiology PMID:34269418 
  12. Leduc-Gaudet JP, Miguez K, Cefis M, Moamer A, Chaffer TJ, Faitg J, et al. Role of autophagy in sepsis-induced skeletal muscle dysfunction, whole-body metabolism, and survival. (2021) bioRxiv
  13. Klionsky, D. J., (...) Leduc-Gaudet JP, (...) et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy PMID:33634751 
  14. Leduc-Gaudet JP, Mayaki D, Reynaud O, Broering F, Chaffer T, Hussain SNA and Gouspillou G.(2020) Parkin Overexpression Attenuates Sepsis-Induced Muscle Wasting. Cells PMID: 32545383
  15. Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub M.B, Guérin A, Finkelchtein M, et al. (2020). Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation. The Journal of physiology PMID: 32539155
  16. Janice Sanchez B, Tremblay, AK, Leduc-Gaudet JP, Hall DT, Kovacs E, Ma JF, Mubaid S, Hallauer, et al. (2019). Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy. Nature Communication PMID: 31519904
  17. Leduc-Gaudet JP*, Reynaud O*, Hussain SNA, Gouspillou G. (2019) Parkin overexpression protects from aging-related loss of muscle mass and strength. *Co-premier auteurThe Journal of Physiology PMID:30614532
  18. Faitg J, Leduc-Gaudet JP, Reynaud O, Ferland G, Gaudreau P, Gouspillou G. (2019) Effects of aging and caloric restriction on mitochondrial morphology and dynamics in rat oxidative and glycolytic muscles. Frontiers in Physiology PMID: 31114501
  19. Moroz N, Maes K, Leduc-Gaudet JP, Goldberg P, Petrof BJ, Mayaki D. et al. (2019) Oxidant regulation of muscle proteolytic pathways in the diaphragm during prolonged mechanical ventilation. Anesthesiology PMID: 31408447
  20. Leduc-Gaudet JP, Reynaud O, Chabot F, Mercier J, Andrich DE, St-Pierre DH, Gouspillou G. (2018) The impact of a short-term high-fat diet on mitochondrial respiration, reactive oxygen species production, and dynamics in oxidative and glycolytic skeletal muscles of young rats. Physiological Reports PMID: 29479852
  21. St-Jean-Pelletier F, Pion CH, Leduc-Gaudet JP, Sgarioto N, Zovile I, Barbat-Artigas S, Reynaud O, Alkaterji F, Lemieux FC, Grenon A, Gaudreau P, Hepple RT, Chevalier S, Belanger M, Morais JA, Aubertin-Leheudre M, Gouspillou G. (2017) The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men. The Journal of Cachexia, Sarcopenia and Muscle PMID: 27897402
  22. Stana F, Vujovic M, Mayaki D, Leduc-Gaudet JP, Leblanc P, Huck L, Hussain SNA. (2017) Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis. Critical Care Medicine PMID: 28538438   
  23. Leduc-Gaudet JP, Picard M, St-Jean Pelletier F, Sgarioto N, Auger MJ, Vallée J, Robitaille R, St-Pierre DH, Gouspillou G. (2015) Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice. Oncotarget PMID: 26053100

Liste complète: https://pubmed.ncbi.nlm.nih.gov/?term=Leduc-Gaudet+JP&cauthor_id=28538438&size=50 

Prix et distinctions

2021: FRQS Postdoctoral Fellowship

2020: Journal of Physiology Early Investigator Prize 2019 - Exercise and Muscle

2016: Vanier Canada Graduate Scholarship (CIHR)

2015: Lieutenant Governor’s Youth Medal (Bronze) 

2015: FRQS Master’s Research Scholarship

2014: Frederick Banting and Charles Best Canada Graduate Scholarship

2014: Strathcona Trust Plaque

Médias