Le corps professoral
Germain, Marc
3539 Léon-Provancher
819 376-5011, poste 3330
Cours enseignés :
Formation :

Post-doctorat en Neurosciences, Université d'Ottawa

Post-doctorat en Immunologie, UBC

Doctorat en Biochimie, McGill University

Maitrise en Biologie Cellulaire et Moléculaire, Université Laval

Bacc. en Biochimie, Université Laval

Intérêts de recherche :

Mitochondries, métabolisme, mort cellulaire, maladies neurodégénératives

Quelques communications et publications :

1. David A Patten, Jacob Wong, Mireille Khacho, Vincent Soubannier, Ryan J Mailloux, Karine Pilon-Larose, Jason G MacLaurin, David S Park, Heidi M. McBride, Laura Trinkle-Mulcahy, Mary Ellen Harpe, Marc Germain* and Ruth S. Slack*. OPA1 dependent cristae modulation is essential for cellular adaptation to metabolic demand. EMBO J. In Press. * Corresponding authors

2. Marc Germain, Angela P. Nguyen, Mireille Khacho, David A Patten, Robert A. Screaton, David S. Park and Ruth S. Slack. LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction. Hum. Mol. Genet., 22, 952-962

3. Daniel J. Klionsky, Fabio C. Abdalla, … Marc Germain et al. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy in Higher Eukaryotes. Autophagy 8, 445-544

4. Marc Germain and Ruth S. Slack (2011) MCL-1 regulates the balance between autophagy and apoptosis, Autophagy 7, 549-551

6. Marc Germain, Angela P. Nguyen, J. Nicole Le Grand, Nicole Arbour, Jacqueline L. Vanderluit, David S. Park, Joseph T. Opferman and Ruth S. Slack (2011) MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated fashion, EMBO J. 30, 395-407.

7. David A Patten, Marc Germain, Melissa Kelly and Ruth S. Slack (2010) ROS: Stuck in the Middle of Neurodegeneration. J. Alzheimers Dis. 20 suppl. 2, S357-367.

8. Natasha C. Chang, Mai Nguyen, Marc Germain and Gordon C. Shore (2010) Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. EMBO J. 29, 606-8

9. Marc Germain and Ruth S. Slack (2010) Dining in with BCL-2: new guests at the autophagy table. Clin. Sci. 118, 173-181.

10. Arezu Jahani-Asl, Marc Germain and Ruth S. Slack (2009) Mitochondria: Joining forces to thwart cell death. BBA 1802, 162-166. 

11. Farshad Forouzandeh, Reza B. Jalili, Marc Germain, Vincent Duronio, and Aziz Ghahary (2008) Skin cells, but not T cells, are resistant to indoleamine 2, 3-dioxygenase (IDO) expressed by allogeneic fibroblasts. Wound Repair regen. 16, 379-387

12. Marc Germain, Jocelyn Milburn and Vincent Duronio (2008) MCL-1 inhibits BAX-dependent apoptosis in the absence of MCL-1/BAX interaction. J. Biol. Chem 283. 6384-6392

13. Farshad Forouzandeh, Reza B. Jalili, Marc Germain, Vincent Duronio, and Aziz Ghahary (2008) Differential Immunosuppressive Effect of Indoleamine 2, 3- Dioxygenase (IDO) on Primary Human CD4+ and CD8+ T Cells. Mol Cell Biochem 309, 1-7

14. Marc Germain and Vincent Duronio (2007) The amino terminus of the anti-apoptotic Bcl-2 homologue Mcl-1 regulates its localization and function. J. Biol. Chem. 282, 32233-32242

15. Matthew R. Warr, Stephane Acoca, Zhiqian Liu, Marc Germain, Mark Watson, Mathieu Blanchette, Simon S. Wing and Gordon C. Shore (2005) BH3-ligand regulates access of MCL-1 to its E3 ligase, FEBS Lett. 579, 5603-5608

16. Marina Stojanovic, Marc Germain, Mai Nguyen and Gordon C. Shore (2005) BAP31 and its caspase cleavage product regulate cell surface expression of tetraspanins and integrin-mediated cell survival, J. Biol. Chem. 280, 30018-30024

17. Jaigi P. Mathai, Marc Germain and Gordon C. Shore (2005) BH3-only BIK regulates BAX,BAK-dependent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death, J. Biol. Chem. 280, 23829-23836

18. Marc Germain, Jaigi P. Mathai and Gordon C. Shore (2005) Endoplasmic Reticulum BIK Initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis, EMBO J. 24, 1546-1556

19. David G. Breckenridge, Marc Germain, Jaigi P. Mathai, Mai Nguyen and Gordon C. Shore (2003). The Endolasmic Reticulum and Apoptosis, Oncogene 22, 8608-8618

20. Marc Germain and Gordon C. Shore (2003) Cellular Distribution of BCL-2 Family Proteins, Sci SKTE 2003, pe10

21. Marc Germain, Jaigi P. Mathai, Gordon C. Shore (2002) BH-3 Only BIK at the Endoplasmic Reticulum to Stimulate Cytochrome c Release from Mitochondria, J. Biol. Chem. 277, 18053-18060

22. Jaigi P. Mathai, Marc Germain, Richard C. Marcellus, Gordon C. Shore (2002) Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signalling by E1A and p53, Oncogene 21, 2534-2544

23. El Bachir Affar, Marc Germain, Eric Winstall, Momchil Vodenicharov, Rashmi G. Shah, Guy S. Salvesen, Guy G. Poirier (2001) Caspase-3-mediated Processing of Poly(ADP-Ribose) Glycohydrolase during Apoptosis, J. Biol Chem 276, 2935-2942

24. El Bachir Affar, Marc Germain, Guy G. Poirier (2000) Role of Poly (ADP-ribose) Polymerase in Cell Death, In: From DNA Damage and Stress Signaling to Cell Death: Poly(ADP-ribosyl)ation Reactions, G. de Murcia and S. Shall Ed., Oxford: Oxford University Press

25. Marc Germain, A. Ivana Scovassi, Guy G. Poirier (2000) Role of Poly(ADP-ribose in Apoptosis, In: Cell Death, the role of Poly(ADP-ribose) Polymerase, S. Szabó Ed., CRC Press, p. 209-226

26. El Bachir Affar, Stéphane Gobeil, Marc Germain, Eric Winstall, Rashmi Shah, Sylvie Bourassa, Jérôme St-Cyr, Claudia Boucher, Guy G. Poirier (2000) Determination of Poly(ADP-ribose) Polymerase Activation and Cleavage during Cell Death, In: Cell Death, the role of Poly(ADP-ribose) Polymerase, S. Szabó Ed., CRC Press, p. 305-322

27. Marc Germain, El Bachir Affar, Damien D’amours, Vishva M. Dixit, Guy S. Salvesen, Guy G. Poirier (1999) Cleavage of Automodified Poly(ADP-Ribose) Polymerase during Apoptosis. Evidence for Involvement of Caspase-7, J. Biol Chem 274, 28379-28384

28. El Bachir Affar, Patrick J. Duriez, Rashmi G. Shah, Eric Winstall, Marc Germain, Claudia Boucher, Sylvie Bourassa, James B. Kirklans, Guy G. Poirier (1999) Immunological determination and size characterization of poly(ADP-ribose) synthesized in vitro and in vivo, Biochim Biophys Acta 1428, 137-146

29. Damien D’Amours, Marc Germain, Vishva M. Dixit, Poirier GG (1998) Proteolysis of Poly(ADP-ribose) Polymerase by Caspase-3 : cleavage kinetics of mono(ADP-ribosyl)ated and DNA-bound substrates, Radiat. Res. 150, 3-10

Prix et distinctions :