Le corps professoral
Germain, Marc
2006A Pierre-Boucher
819 376-5011, poste 3330
Cours enseignés :
Automne 2023
  • BCL1004 - Biologie cellulaire : organisation et fonctions des cellules
  • BIP6034 - Sujets spéciaux I en biologie cellulaire et moléculaire
  • BIP6035 - Sujets spéciaux II en biologie cellulaire et moléculaire
  • PSL1004 - Physiologie humaine I
Formation :

Post-doctorat en Neurosciences, Université d'Ottawa

Post-doctorat en Immunologie, UBC

Doctorat en Biochimie, McGill University

Maitrise en Biologie Cellulaire et Moléculaire, Université Laval

Bacc. en Biochimie, Université Laval

Intérêts de recherche :

Mitochondries, métabolisme, mort cellulaire, maladies neurodégénératives

Quelques communications et publications :
  1. Ilamathi HS*, Benhammouda S*, Desrochers-Goyette J*, Lines MA, Germain M. (2022). DRP1 regulates endoplasmic reticulum sheets to control mitochondrial DNA replication and segregation. iScience, in revision
  2. Lounas A, Lebrun A, Laflamme I, Vernoux N, Savage J, Tremblay, M-E, Germain M, Richard F. (2022). Mitochondrial morphology in porcine cumulus cells: a 3D perspective. Scientific Reports. 12:15403: 1-10.
  3. Bilen M, Benhammouda S, Slack RS, Germain M. (2022). The integrated stress response as a key pathway downstream of mitochondrial dysfunction. Current Opinion in Physiology. 28:100555: 1-12.
  4. Tlili M, Acevedo H, Descoteaux A, Germain M, Heinonen KM. (2022). Cell- intrinsic Wnt4 ligand regulates mitochondrial oxidative phosphorylation in macrophages. Biol. Chem.298:102193: 1-15.
  5. Ilamathi HS*, Ouellet M*, Sabouny R, Desrochers- Goyette J*, Lines MA, Pfeffer G, Shutt TE, Germain (2021). Mitomate Tracker: an automated tool to quantify nucleoid distribution. Sci. Rep. 11:22755: 1-14.
  6. Benhammouda S*, Vishwakarma A*, Gatti P*, Germain M*. (2021). Mitochondria Endoplasmic Reticulum Contact Sites (ERMCS): Tools to study organelle interaction. Frontiers in Cell Dev. Biol. 9:789959
  7. Klionski D et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (Fourth Edition) [The authors include a large number of labs working on autophagy (including my lab) by alphabetical order]. Autophagy. 17: 1-382.
  8. Amari L*, Germain M. (2021). Mitochondrial Extracellular Vesicles – Origins and Roles. Front. Mol. Neurosci. 14:767219.
  9. Todkar K*, Chikhi L*, Desjardins V*, El-Mortada F*, Pépin G, Germain M. (2021). Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs. Nature Communications. 12:1971: 1-12.
  10. Costa G, Caputi FF, Serra M, Simola N, Rullo L, Stamatakos S, Sanna F, Germain M, Martinoli MG, Candeletti S, Morelli M, Romualdi P. (2021). Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related Differences. Front. Pharmacol.12:713486: 1-16.
  11. Gatti P*, Ilamathi HS*, Todkar K*, Germain M. (2020). Mitochondria Targeted Viral Replication and Survival Strategies—Prospective on SARS-CoV-2. Front. Pharmacol.11:578599: 1-9.
  12. Todkar K*, Chikhi L*, Germain M. (2019). Mitochondrial interaction with the endosomal compartment in endocytosis and mitochondrial transfer. Mitochondrion. 49: 284-288.
  13. Almutawa W, Smith C, Sabouny R, Smit RB, Zhao T, Wong R, Lee-Glover L, Desrochers-Goyette J*, Ilamathi HS*, Care4Rare Canada Consortium, Suchowersky O, Germain M, Mains PE, Parboosingh JS, Pfeffer G, Innes AM, Shutt TE. (2019). The R941L mutation in MYH14 disrupts mitochondrial fission and causes peripheral neuropathy. EBioMedicine. 45: 379-392.
  14. Lounas A*, Vernoux N, Germain M, Tremblay ME, Richard FJ. (2019). Mitochondrial sub-cellular localization of cAMP-specific phosphodiesterase 8A in ovarian follicular cells. Sci. 9:12493: 1-10.
  15. Patten DA, Ouellet M*, Allan DS, Baird S, Germain M, Harper ME, Richardson, R. (2018). Mitochondrial adaptation following ionizing radiation in human mesenchymal stem cells. FASEB J. May 21:fj201801483RR: 9263-9278.
  16. Ouellet M*, Guillebaud G*, Gervais V* Lupien St-Pierre D, Germain M. (2017). A novel algorithm identifies stress-induced alterations in mitochondrial connectivity and innermembrane structure from confocal images. PLoS Computational Biology. 13(6): e1005612.
  17. St-Cyr Giguère F, Attiori Essis S, Chagniel L, Germain M, Cyr M, Massicotte G. (2017). The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices. Brain Research. 1658: 51-59.
  18. Todkar K*, Ilamathi HS*, Germain M. (2017). Mitochondria and Lysosomes: Discovering Bonds. Frontiers in Cell and Developmental Biology. 5(Art. 106): 1-7.
  19. Achour I, Arel-Dubeau AM, Renaud J, Legrand M, Attard E, Germain M, Martinoli MG. (2016). Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model. International Journal of Molecular Sciences. 17: pii: E1293.
  20. Khacho M, Clark A, Svoboda DS, Azzi J, MacLaurin J, Meghaizel C, Sesaski H, Lagace DC, Germain M, Harper ME, Park DS, Slack RS. (2016). Mitochondrial dynamics directs the identity and self-renewal capacity of stem cells by regulating a nuclear transcriptional program. Cell Stem Cell. 19(2): 232-247.
  21. Demers-Lamarche J*, Guillebaud G*, Todkar K*, Tlili M*, Bélanger N*, Nguyen AP, Grondin M*, Michel J, Germain M. (2016). Loss of mitochondrial function impairs lysosomes. J. Biol. Chem. 291(19): 10263-10276.
  22. Germain M. (2015). OPA1 and mitochondrial solute carriers in bioenergetic metabolism. Molecular and Cellular Oncology. 2(2): e982378.
  23. Patten DA*, Wong J, Khacho M, Soubannier V, Mailloux RJ, Pilon-Larose K, MacLaurin J, Park DS, McBride H, Trinkle-Mulcahy L, Harper ME, Germain M†, Slack RS† (†Co-corresponding authors). (2014). OPA1 senses metabolic changes through SLC25 family proteins to regulate mitochondrial structure and function. EMBO J. 33(22): 2676-2691.
  24. Arel-Dubeau AM, Longpré F, Bournival J, Tremblay C, Demers-Lamarche J*, Haskova P, Attard E, Germain M, Martinoli MG. (2014). Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neurons. Oxidative Medicine and Cellular Longevity. 425496: 1-15.
Prix et distinctions :
5 décembre 2023 13 h 31